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Techniques in Coloproctology

, Volume 23, Issue 10, pp 973–980 | Cite as

Visualization and quantification of anastomotic perfusion in colorectal surgery using near-infrared fluorescence

  • S. Hayami
  • K. Matsuda
  • H. Iwamoto
  • M. Ueno
  • M. Kawai
  • S. Hirono
  • K. Okada
  • M. Miyazawa
  • K. Tamura
  • Y. Mitani
  • Y. Kitahata
  • Y. Mizumoto
  • Hiroki YamaueEmail author
Original Article

Abstract

Background

Anastomotic leakage (AL) is one of the most troublesome complications in colorectal surgery. Recently, near-infrared fluorescence (NIRF) imaging has been used intraoperatively to detect sentinel lymph nodes and visualize the blood supply at the region of interest (ROI). The aim of this study was to evaluate the role of visualization and quantification of bowel perfusion around the anastomosis using NIRF system in predicting AL.

Methods

A prospective study was conducted on patients who had laparoscopic surgery for colorectal cancer at our institution. Perfusion of the anastomosis was evaluated with NIRF imaging after intravenous injection of indocyanine green (ICG). The time course of fluorescence intensity was recorded by an imaging analyzer We measured the time from ICG injection to the beginning of fluorescence (T0), maximum intensity (Imax), time to reach Imax (Tmax), time to reach Imax 50% (\(T_{{{ \text{max} }_{1/2} }}\)) and slope (S) after the anastomosis.

Results

Tumor locations were as follows; cecum: 2, ascending colon: 2, transverse colon: 7, descending colon: 1, sigmoid colon: 2, rectosigmoid colon: 3 and rectum: 6 (one case with synchronous cancer). All operations were performed laparoscopically. Four patients were diagnosed with or suspected to have AL (2 patients with grade B anastomotic leakage after low anterior resection, 1 patient with minor leakage in transverse colon resection and 1 patient needing re-anastomosis intraoperatively in transverse colon resection). T0 was significantly longer in the AL group than in patients without AL (64.3 ± 27.6 and 18.2 ± 6.6 s, p = 2.2 × 10−3).

Conclusions

Perfusion of the anastomosis could be successfully visualized and quantified using NIRF imaging with ICG. T0 might be a useful parameter for prediction of AL.

Keywords

Anastomotic leakage Perfusion Optical imaging Fluorescence imaging COLON/surg RECTUM/surg 

Abbreviations

AL

Anastomotic leakage

NIRF

Near-infrared fluorescence

ICG

Indocyanine green

UMIN-CTR

University Hospital Medical Information Network Clinical Trial Registry

FEEA

Functional end-to-end anastomosis

DST

Double stapling technique

SPIES

Storz Professional Image Enhancement system

ROI

Region of interest

ASA

American Society of Anesthesiologists

UICC TNM classification

The Union for International Cancer Control’s tumor-node-metastasis classification

ISGRC

The International Study Group of Rectal Cancer

Notes

Acknowledgements

We acknowledge editing and proofreading by Benjamin Phillis, Clinical Study Support Center, Wakayama Medical University.

Funding

There is no funding or material support on this study.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study protocol was approved by Wakayama Medical University Ethical Committee (approval number: 1418) and registered on University Hospital Medical Information Network (UMIN) Clinical Trial Registry (UMIN-CTR, UMIN000022876).

Informed consent

Written informed consent was obtained from all participants included in this study.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • S. Hayami
    • 1
  • K. Matsuda
    • 1
  • H. Iwamoto
    • 1
  • M. Ueno
    • 1
  • M. Kawai
    • 1
  • S. Hirono
    • 1
  • K. Okada
    • 1
  • M. Miyazawa
    • 1
  • K. Tamura
    • 1
  • Y. Mitani
    • 1
  • Y. Kitahata
    • 1
  • Y. Mizumoto
    • 1
  • Hiroki Yamaue
    • 1
    Email author
  1. 1.Second Department of Surgery, School of MedicineWakayama Medical University811-1, Kimiidera, WakayamaJapan

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