Techniques in Coloproctology

, Volume 22, Issue 8, pp 617–621 | Cite as

Label-free quantitative optical assessment of human colon tissue using spatial frequency domain imaging

  • S. Nandy
  • W. ChapmanJr.
  • R. Rais
  • I. González
  • D. Chatterjee
  • M. Mutch
  • Q. ZhuEmail author
Technical Advances


Colorectal cancer remains the second most common malignancy diagnosed worldwide and accounts for over 100,000 new cases annually in the US [1]. Current treatment methods typically involve surgical resection with selective use of radiation and chemotherapy depending on disease site and stage. Some of the greatest gains in survival, however, have come from aggressive endoscopic screening. In particular, colonoscopy has led to detection of colorectal malignant disease at an earlier stage while also providing therapeutic options including resection of early neoplastic disease [2].

However, several scenarios continue to complicate endoscopic surveillance including identification and assessment of flat neoplasia like sessile polyps and oncologic restaging following neoadjuvant therapy; these can harbor early cancers but remain difficult to identify with standard endoscopic techniques. Additionally, quantitative evaluation of the mucosa for residual rectal cancer after...



This work was supported in part by National Institutes of Health R01CA151570 (QZ) and T32 CA009621 (WC). The research protocol described herein was approved by Institutional Review Board (IRB# 201707066).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The research protocol described herein was approved by the Washington University School of Medicine Institutional Review Board (IRB# 201707066).

Informed consent

Each patient that participated in the study consented in writing.


  1. 1.
    Siegel RL, Miller KD, Fedewa SA et al (2017) Colorectal cancer statistics, 2017. CA Cancer J Clin 67(3):177–193CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Pan J, Xin L, Ma YF, Hu LH, Li ZS (2016) Colonoscopy reduces colorectal cancer incidence and mortality in patients with non-malignant findings: a meta-analysis. Am J Gastroenterol 111(3):355–365CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Rex DK, Ahnen DJ, Baron JA et al (2012) Serrated lesions of the colorectum: review and recommendations from an expert panel. Am J Gastroenterol 107(9):1315–1329CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Laughney AM, Krishnaswamy V, Rizzo EJ et al (2013) Spectral discrimination of breast pathologies in situ using spatial frequency domain imaging. Breast Cancer Res BCR 15(4):R61CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Nandy S, Hagemann IS, Powell MA, Siegel C, Zhu Q (2018) Quantitative multispectral ex vivo optical evaluation of human ovarian tissue using spatial frequency domain imaging. Biomed Opt Express 9(5):2451–2456CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Department of Biomedical EngineeringWashington UniversitySt. LouisUSA
  2. 2.Department of Surgery, Section of Colon and Rectal SurgeryWashington University School of MedicineSt. LouisUSA
  3. 3.Department of Pathology and ImmunologyWashington University School of MedicineSt. LouisUSA
  4. 4.Department of RadiologyWashington University School of MedicineSt. LouisUSA

Personalised recommendations