Label-free quantitative optical assessment of human colon tissue using spatial frequency domain imaging
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Colorectal cancer remains the second most common malignancy diagnosed worldwide and accounts for over 100,000 new cases annually in the US . Current treatment methods typically involve surgical resection with selective use of radiation and chemotherapy depending on disease site and stage. Some of the greatest gains in survival, however, have come from aggressive endoscopic screening. In particular, colonoscopy has led to detection of colorectal malignant disease at an earlier stage while also providing therapeutic options including resection of early neoplastic disease .
However, several scenarios continue to complicate endoscopic surveillance including identification and assessment of flat neoplasia like sessile polyps and oncologic restaging following neoadjuvant therapy; these can harbor early cancers but remain difficult to identify with standard endoscopic techniques. Additionally, quantitative evaluation of the mucosa for residual rectal cancer after...
This work was supported in part by National Institutes of Health R01CA151570 (QZ) and T32 CA009621 (WC). The research protocol described herein was approved by Institutional Review Board (IRB# 201707066).
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Conflict of interest
The authors declare that they have no conflict of interest.
The research protocol described herein was approved by the Washington University School of Medicine Institutional Review Board (IRB# 201707066).
Each patient that participated in the study consented in writing.