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International Journal of Clinical Oncology

, Volume 24, Issue 10, pp 1171–1181 | Cite as

Immune checkpoint inhibitor-induced sarcoidosis-like granulomas

  • Pooja H. Rambhia
  • Barbara Reichert
  • Jeffrey F. Scott
  • Ashley N. Feneran
  • Jordan A. Kazakov
  • Kord Honda
  • Henry Koon
  • Meg R. GerstenblithEmail author
Review Article

Abstract

Immune checkpoint inhibitors targeting the cytotoxic T lymphocyte-associated antigen-4 and programmed cell death-1 receptors have transformed the treatment of melanoma and other cancers. These therapies are associated with a number of side effects, including immune-related adverse events. Sarcoidosis-like granulomas (SLGs) are important immune checkpoint inhibitor-related reactions to recognize as SLGs can mimic disease progression and accordingly impact treatment decisions. We systematically review reports of immune checkpoint inhibitor-induced SLGs in cancer patients and discuss potential underlying pathophysiological mechanisms.

Keywords

Drug reactions Melanoma Immune checkpoint inhibitor PD-1 CTLA-4 Sarcoidosis-like granuloma 

Abbreviations

BAL

Bronchoalveolar lavage

CTLA-4

Cytotoxic T-lymphocyte-associated antigen 4

IFN-γ

Interferon gamma

IL

Interleukin

iRAEs

Immune-related adverse events

NR

Not reported

PD-1

Programmed death-1

SLG

Sarcoidosis-like granuloma

TCR

T-cell receptor

Th-1

T helper-1

Th-17

T helper-17

TNF-α

Tumor necrosis factor alpha

Notes

Funding

This study was funded by the Char and Chuck Fowler Foundation, RES119774.

Compliance with ethical standards

Conflict of interest

Author PHR declares that she has no conflict of interest. Author BR declares that she has no conflict of interest. Author JFS declares that he has no conflict of interest. Author ANF declares that she has no conflict of interest. Author JAK declares that he has no conflict of interest. Author KH declares that he has no conflict of interest. Author HK owns stock in Company BMS. Author MRG has received research grants from the Char and Chuck Fowler Family Foundation.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Japan Society of Clinical Oncology 2019

Authors and Affiliations

  1. 1.Department of DermatologyUniversity Hospitals Cleveland Medical Center/Case Western Reserve University School of MedicineClevelandUSA
  2. 2.Pulmonary/Critical Care Division, Department of MedicineUniversity Hospitals Cleveland Medical Center/Case Western Reserve University School of MedicineClevelandUSA
  3. 3.Case Comprehensive Cancer CenterCase Western Reserve University School of MedicineClevelandUSA
  4. 4.Department of Medicine, Hematology and Oncology DivisionUniversity Hospitals Cleveland Medical Center/Case Western Reserve University School of MedicineClevelandUSA

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