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The impact of programmed cell death-ligand 1 (PD-L1) and CD8 expression in grade 3 endometrial carcinomas

  • Stylianos VagiosEmail author
  • Petros Yiannou
  • Elpida Giannikaki
  • Triada Doulgeraki
  • Christos Papadimitriou
  • Alexandros Rodolakis
  • Afroditi Nonni
  • Athanassios Vlachos
  • Kitty Pavlakis
Original Article
  • 26 Downloads

Abstract

Background

To evaluate the expression of programmed cell death-ligand 1 (PD-L1) and CD8 in high-grade endometrial carcinomas and relate it to several clinicopathological parameters.

Methods

One hundred and one (101) patients with high-grade endometrial carcinomas who were completely surgically staged were included in this study. PD-L1 and CD8 + expression was evaluated by immunohistochemistry.

Results

In our cohort, 47 women (46.5%) had endometrioid carcinomas and 54 patients (53.5%) were diagnosed with non-endometrioid cancers. In endometrioid carcinomas, there was a significantly higher rate of positivity for PD-L1 expression (p = 0.042) and of intraepithelial CD8 + cell counts (p = 0.004) as opposed to non-endometrioid cancers. There were no significant relationships with any of the other clinicopathological features under study. Univariate and multivariate analysis revealed that only high intraepithelial CD8 + counts (p = 0.01) was associated with longer progression-free survival. Tumors positive for PD-L1 and high intraepithelial CD8 expression were mainly of endometrioid histology, whilst PD-L1-positive/CD8 low and PD-L1-negative/CD8 low tumors were mostly non-endometrioid carcinomas (p = 0.01). PD-L1 negative/CD8 high tumors had the longest progression-free survival (p = 0.032).

Conclusions

In grade 3 endometrial carcinomas, both of endometrioid and non-endometrioid type, high intraepithelial CD8 + counts represent an independent favorable prognostic factor and when related to PD-L1-negative tumors, a longer progression-free survival can be predicted. Immunotherapy could probably be considered for PD-L1-positive/CD8 + high tumors, which were mostly of endometrioid histology.

Keywords

PD-L1 CD8 Endometrial cancer 

Notes

Acknowledgements

This research work was supported by the Onassis Foundation—Scholarship ID: G ZO 001-1/2018-2019.

Compliance with ethical standards

Conflict of interest

Onassis Foundation did not influence on the decision to submit this manuscript or on its content. We declare that we have no conflict of interest.

Supplementary material

10147_2019_1484_MOESM1_ESM.docx (12 kb)
Supplementary file1 (DOCX 12 kb)

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Copyright information

© Japan Society of Clinical Oncology 2019

Authors and Affiliations

  • Stylianos Vagios
    • 1
    Email author
  • Petros Yiannou
    • 2
  • Elpida Giannikaki
    • 3
  • Triada Doulgeraki
    • 2
  • Christos Papadimitriou
    • 4
  • Alexandros Rodolakis
    • 5
  • Afroditi Nonni
    • 1
  • Athanassios Vlachos
    • 6
  • Kitty Pavlakis
    • 1
    • 2
  1. 1.Pathology DepartmentNational and Kapodistrian University of AthensAthensGreece
  2. 2.Pathology Department“IASO” Women’s HospitalAthensGreece
  3. 3.Pathology DepartmentVenizeleio-Pananeio General HospitalHeraklionGreece
  4. 4.Oncology Unit, 2nd Department of Surgery, Aretaieion HospitalNational and Kapodistrian University of AthensAthensGreece
  5. 5.1st Department of Obstetrics and Gynecology, Alexandra HospitalNational and Kapodistrian University of AthensAthensGreece
  6. 6.Department of Gynecological Oncology“IASO” Women’s HospitalAthensGreece

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