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International Journal of Clinical Oncology

, Volume 24, Issue 10, pp 1182–1189 | Cite as

Frequency and predictors of detecting early locoregional recurrence/disease progression of oral squamous cell carcinoma with high-risk factors on imaging tests before postoperative adjuvant radiotherapy

  • Yuichi Kibe
  • Naoki NakamuraEmail author
  • Hirofumi Kuno
  • Takashi Hiyama
  • Ryuichi Hayashi
  • Sadamoto Zenda
  • Atsushi Motegi
  • Hidehiro Hojo
  • Masaki Nakamura
  • Takaki Ariji
  • Hajime Oyoshi
  • Tetsuo Akimoto
Original Article
  • 65 Downloads

Abstract

Background

To clarify the frequency and predictors of detecting early locoregional recurrence/disease progression (LR/DP) during the interval between surgery and postoperative adjuvant radiotherapy with/without chemotherapy in patients with oral squamous cell carcinoma.

Methods

Data on 65 patients who had undergone the initial radical surgery for previously untreated oral squamous cell carcinoma which were scheduled to receive adjuvant radiotherapy with/without chemotherapy were reviewed.

Results

Of the 65 patients, 63 (97%) were margin-positive/close and/or extracapsular extension-positive (hereinafter, high-risk factors). Eighteen (28%) patients had abnormal findings suggestive of LR/DP on postoperative imaging. Fifteen (23%) patients were diagnosed with LR/DP and treatment policy was changed. Univariate and multivariate analyses revealed higher frequencies of abnormal findings suggestive of LR/DP (univariate/multivariate analysis, p = 0.020/0.036), diagnosing of LR/DP, and changing the treatment policy (univariate/multivariate analysis, p = 0.042/0.046), among the patients who underwent postoperative diagnostic imaging tests or radiotherapy-planning contrast-enhanced (CE) CT without diagnostic imaging tests as compared with those who underwent radiotherapy-planning non-CECT without such tests.

Conclusion

The frequency of detecting of early LR/DP before postoperative adjuvant treatment in oral squamous cell carcinoma patients with high-risk factors was high. Furthermore, postoperative diagnostic imaging tests and radiotherapy-planning CECT may be useful to detect early LR/DP in oral squamous cell carcinoma patients before postoperative adjuvant therapy.

Keywords

Oral Squamous cell carcinoma Adjuvant radiotherapy Postoperative Surgery Recurrence 

Notes

Compliance with ethical standards

Conflict of interest

All authors have nothing to declare.

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Copyright information

© Japan Society of Clinical Oncology 2019

Authors and Affiliations

  • Yuichi Kibe
    • 1
  • Naoki Nakamura
    • 1
    Email author
  • Hirofumi Kuno
    • 2
  • Takashi Hiyama
    • 2
  • Ryuichi Hayashi
    • 3
  • Sadamoto Zenda
    • 1
  • Atsushi Motegi
    • 1
  • Hidehiro Hojo
    • 1
  • Masaki Nakamura
    • 1
  • Takaki Ariji
    • 1
  • Hajime Oyoshi
    • 1
  • Tetsuo Akimoto
    • 1
  1. 1.Department of Radiation Oncology and Particle TherapyNational Cancer Center Hospital EastKashiwaJapan
  2. 2.Department of Diagnostic RadiologyNational Cancer Center Hospital EastKashiwaJapan
  3. 3.Department of Head and Neck SurgeryNational Cancer Center Hospital EastKashiwaJapan

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