International Journal of Clinical Oncology

, Volume 24, Issue 10, pp 1256–1263 | Cite as

Predictors of favorable survival after secondary cytoreductive surgery for recurrent endometrial cancer

  • Ayumi ShikamaEmail author
  • Takeo Minaguchi
  • Wataru Takao
  • Yoshihiko Hosokawa
  • Keiko Nishida
  • Nobutaka Tasaka
  • Azusa Akiyama
  • Manabu Sakurai
  • Hiroyuki Ochi
  • Toyomi Satoh
Original Article



The selection criteria for secondary cytoreductive surgery (SCS) for recurrent endometrial cancer (EC) remain to be defined. The present study aimed to identify predictors for favorable survival after SCS for the disease.


We retrospectively reviewed the medical records of 112 patients who relapsed by 2016 among 1052 who were diagnosed with primary EC between 1985 and 2014. Characteristics associated with overall survival (OS) after SCS were identified using univariate and multivariate analyses.


Twenty-nine of the 112 patients who relapsed underwent SCS. Complete resection was achieved in 18 (62%) patients, whose OS after SCS was significantly better than that of patients receiving incomplete resection (68 vs. 20 months; p = 0.001). Endometrioid histology and performance status (PS) 0 were significant and independent factors for a favorable OS (p = 0.005, and 0.049). The OS of patients with both factors was better than patients with one or no factors (median 75, 19 and 4 months; p = 0.001 and 0.00001). The number of predictors was associated with the rate of complete resection (p = 0.001).


Patients with endometrioid histology and PS 0 should be offered SCS for recurrent EC. Prospective trials are warranted to verify this proposal.


Secondary cytoreductive surgery Recurrent endometrial cancer Survival 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

10147_2019_1469_MOESM1_ESM.pdf (56 kb)
Supplementary material 1 (PDF 56 kb)
10147_2019_1469_MOESM2_ESM.pdf (100 kb)
Supplementary material 2 (PDF 99 kb)


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Copyright information

© Japan Society of Clinical Oncology 2019

Authors and Affiliations

  • Ayumi Shikama
    • 1
    Email author
  • Takeo Minaguchi
    • 1
  • Wataru Takao
    • 1
  • Yoshihiko Hosokawa
    • 1
  • Keiko Nishida
    • 1
  • Nobutaka Tasaka
    • 1
  • Azusa Akiyama
    • 1
  • Manabu Sakurai
    • 1
  • Hiroyuki Ochi
    • 1
  • Toyomi Satoh
    • 1
  1. 1.Department of Obstetrics and Gynecology, Faculty of MedicineUniversity of TsukubaTsukubaJapan

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