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International Journal of Clinical Oncology

, Volume 24, Issue 10, pp 1301–1310 | Cite as

Clinical significance of prognostic nutritional index (PNI) in malignant melanoma

  • Cem MiriliEmail author
  • Ali Yılmaz
  • Serkan Demirkan
  • Mehmet Bilici
  • Salim Basol Tekin
Original Article

Abstract

Purpose

Nutrition and inflammation play a crucial role in the development of cancer. The prognostic value of the prognostic nutritional index (PNI) has been confirmed in some types of human cancers. However, few studies are available indicating its prognostic power in patients with malignant melanoma (MM). Thus, we aimed to identify baseline peripheral blood biomarkers to predict the outcome of MM patients

Material and methods

Data of 101 patients with MM were evaluated retrospectively. Associations between clinical and histopathological parameters with overall survival (OS) and progression-free survival (PFS) were analyzed using Kaplan–Meier curves and compared by the log-rank test. The optimal cutoff values were determined by a receiver operating characteristic (ROC) curve analysis. Neutrophil–lymphocyte ratio (NLR), systemic immune-inflammation index (SII) and PNI were grouped based on a cutoff points 2.18, 547.1, and 40.1, respectively. Univariate and multivariate analyses were used to assess their prognostic values for overall survival (OS).

Results

Lower NLR ( < 2.18), SII ( < 547.1) and higher PNI ( ≥ 40.1) were linked with a longer PFS and OS in patients with MM, as reflected in the Kaplan–Meier analyses. In univariate analysis, TNM stage, Breslow thickness, Clark stage, ulceration, Ki67 status, LDH, NLR, SII, and PNI were significantly associated with OS. Multivariate analysis identified TNM stage, ulceration, LDH and PNI as an independent predictor of OS in patients with MM.

Conclusion

PNI can be regarded as a novel independent prognostic factor for predicting OS in MM.

Keywords

Malignant melanoma Prognostic nutritional index Neutrophil–lymphocyte ratio Systemic immune-inflammation index 

Notes

Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Japan Society of Clinical Oncology 2019

Authors and Affiliations

  1. 1.Department of Medical OncologyAtaturk University Faculty of MedicineYakutiyeTurkey
  2. 2.Department of DermatologyKatip Çelebi University Ataturk Education and Research HospitalİzmirTurkey

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