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Japan Society of Gynecologic Oncology guidelines 2017 for the treatment of uterine cervical cancer

  • Yasuhiko Ebina
  • Mikio Mikami
  • Satoru Nagase
  • Tsutomu Tabata
  • Masanori Kaneuchi
  • Hironori Tashiro
  • Masaki Mandai
  • Takayuki Enomoto
  • Yoichi Kobayashi
  • Hidetaka Katabuchi
  • Nobuo Yaegashi
  • Yasuhiro Udagawa
  • Daisuke Aoki
Special Article

Abstract

The Japan Society of Gynecologic Oncology (JSGO) Guidelines 2017 for the Treatment of Uterine Cervical Cancer are for the purpose of providing standard treatment strategies for cervical cancer, indicating treatment methods currently considered appropriate for cervical cancer, minimizing variances in treatment methods among institutions, improving the safety of treatment and prognosis of diseases, reducing the economic and psychosomatic burden of patients by promoting performance of appropriate treatment, and enhancing mutual understanding between patients and healthcare professionals. The guidelines were prepared through consensus of the JSGO Guideline Committee, based on careful review of evidence gathered through the literature searches and in view of the medical health insurance system and actual clinical practice situations in Japan. The guidelines comprise eight chapters and five algorithms. The main features of the 2017 revision are as follows: (1) evidence was collected using a search formula and with cooperation of the Japan Library Association. The bibliographical search formula was placed at the end of the book; (2) regarding clinical questions (CQs) where evidence or clinical inspection in Japan was lacking, opinions of the Guidelines Committee were described as “proposals for future directions”; (3) cervical intraepithelial neoplasia (CIN) 3 and adenocarcinoma in situ (AIS) were treated as a cervical precancerous lesion; (4) the CQs of endoscopic surgery, radical trachelectomy, and sentinel node biopsy were newly added in Chapter 3, “primary treatment for stage IB–II cervical cancer”; and (5) the CQ about hormone replacement therapy after cancer treatment was newly established. Each recommendation is accompanied by a classification of recommendation categories based on the consensus reached by the Guideline Committee members. Here, we present the English version of the JSGO Guidelines 2017 for the Treatment of Uterine Cervical Cancer.

Keywords

Uterine cervical cancer Clinical practice guidelines Surgery Chemotherapy Irradiation Recurrence 

Abbreviations

AIS

Adenocarcinoma in situ

CCRT

Concurrent chemoradiotherapy

CIN

Cervical intraepithelial neoplasia

COIs

Conflicts of interests

CQs

Clinical questions

CTV

Clinical target volume

EORTC

European Organization for Research and Treatment of Cancer

FIGO

International Federation of Gynecology and Obstetrics

Gy

Gray

HPV

Human papillomavirus

HRT

Hormone replacement therapy

HSIL

High-grade squamous intraepithelial lesion

IMRT

Intensity-modulated radiation therapy

JCOG

Japan Clinical Oncology Group

JGOG

Japanese Gynecologic Oncology Group

JSCO

Japan Society of Clinical Oncology

JSGO

Japan Society of Gynecologic Oncology

LSIL

Low-grade squamous intraepithelial lesion

Minds

Medical Information Network Distribution Service

NAC

Neoadjuvant chemotherapy

NCCN

National Comprehensive Cancer Network

PTV

Planning target volume

QOL

Quality of life

RCT

Randomized controlled trial

RTOG

Radiation Therapy Oncology Group

SIL

Squamous intraepithelial lesion

TC

Paclitaxel plus carboplatin

TP

Paclitaxel plus cisplatin

WBRT

Whole-brain radiation therapy

WHO

World Health Organization

3D-CRT

3 dimensional-conformal radiotherapy

Notes

Acknowledgements

We thank the Japanese Society of Obstetrics and Gynecology (JSOG), the Japan Society of Clinical Oncology (JSCO), the Japan Society of Gynecologic and Obstetric Endoscopy and Minimally Invasive Therapy, the Japanese Gynecologic Oncology Group (JGOG), the Japan Association of Obstetricians and Gynecologists (JAOG), the Japan Society of Pathology (JSP), the Japanese Society for Radiation Oncology (JASTRO) for their comments and contributions throughout the project. We also acknowledge the clerical and technical assistance by Ms Toshie Yasuda of JSGO and Ms Yuriko Adachi of Kanehara CO., LTD.

Members of Guidelines Committee (alphabetical order)

Masanori Kaneuchi, Hidetaka Katabuchi, Mikio Mikami, Satoru Nagase, Tsutomu Tabata. Yasuhiro Udagawa, Nobuo Yaegashi.

Members of guidelines drafting committee (alphabetical order)

Tsukasa Baba, Yasuhiko Ebina, Takayuki Enomoto, Kazuhiko Hayashi, Yasuyuki Hirashima, Takashi Iwata, Shingo Kato, Noriyuki Katsumata, Atsumi Kojima, Tetsuji Kurokawa, Masaki Mandai, Yoshiki Mikami, Toshinari Muramatsu, Yutaka Nagai, Hidekatsu Nakai, Kentaro Nakayama, Hitoshi Niikura, Katsutoshi Oda, Hideyuki Ohtake, Masayuki Sekine, Muneaki Shimada, Tsutomu Tabata, Kiyomi Takaishi, Kiyoshi Takamatsu, Kazuhiro Takehara, Hironori Tashiro, Takafumi Toita, Satoshi Yamaguchi, Masanori Yasuda, Kiyoshi Yoshino.

Members of guidelines evaluation committee (alphabetical order)

Daisuke Aoki, Yoichi Aoki, Takuma Fujii, Keiichi Fujiwara, Toru Hachisuga, Toshio Hamatani, Kenichi Hrano, Kazuhiko Ino, Atsuko Itakura, Kiyoshi Ito, Osamu Iwanari, Seiryu Kamoi, Takahiro Kasamatsu, Naoki Kawamura, Hiroaki Kobayashi, Hiroshi Kobayashi, Takeshi Kodaira, Kaneyuki Kubushiro, Etsuko Miyagi, Mika Mizuno, Kenichiro Morishige, Tetsuro Nagasaka, Toshiaki Nakamura, Masahide Ohmichi, Aikou Okamoto, Takashi Onda, Tsuyoshi Saito, Toshiaki Saito, Noriaki Sakuragi, Toyomi Sato, Tadashi Shiraishi, Toru Sugiyama, Nao Suzuki, Mitsuaki Suzuki, Masashi Takano, Nobuhiro Takeshima, Takashi Uno, Kimio Ushijima, Yoh Watanabe, Hiroko Yokota, Hiroyuki Yoshikawa.

Patient advocacy group “Katorea no Mori”.

Funding

Preparation of these guidelines was funded by the JSGO. No financial support was received from any other organization or corporation.

Compliance with ethical standards

Conflict of interest

(1) The Conflicts of Interest Committee of the JSGO discloses information on real or potential COIs of the members of the Drafting and Evaluation Committees for the Guidelines, as well as other relevant parties. The information can be confirmed via the Policy on Conflicts of Interest among Clinical Cancer Researchers, which can be viewed at http://www.jsgo.or.jp/topics/index01.html (prepared by JSGO; in Japanese). The following corporations were disclosed by self‑declaration of the Drafting Committee members. ASKA Pharmaceutical Co., Ltd.; Otsuka Pharmaceutical Co., Ltd.; TSUMURA & Co.; Zeria Pharmaceutical Co., Ltd.; Chugai Pharmaceutical Co., Ltd.; Bayer Yakuhin Ltd.; Pfizer Japan Inc.; and Roche Diagnostics Co., Ltd. (2) Each recommendation was determined through consensus of all committee members and was not influenced by the interests of specific organizations, products, or technologies.

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Copyright information

© Japan Society of Clinical Oncology 2018

Authors and Affiliations

  • Yasuhiko Ebina
    • 1
  • Mikio Mikami
    • 2
  • Satoru Nagase
    • 3
  • Tsutomu Tabata
    • 4
  • Masanori Kaneuchi
    • 5
  • Hironori Tashiro
    • 6
  • Masaki Mandai
    • 7
  • Takayuki Enomoto
    • 8
  • Yoichi Kobayashi
    • 9
  • Hidetaka Katabuchi
    • 6
  • Nobuo Yaegashi
    • 10
  • Yasuhiro Udagawa
    • 11
  • Daisuke Aoki
    • 12
  1. 1.1Department of Obstetrics and GynecologyKobe University Graduate School of MedicineKobeJapan
  2. 2.Department of Obstetrics and GynecologyTokai University School of MedicineIseharaJapan
  3. 3.Department of Obstetrics and Gynecology, Faculty of MedicineYamagata UniversityYamagataJapan
  4. 4.Department of Obstetrics and GynecologyMie University Faculty of MedicineTsuJapan
  5. 5.Department of Obstetrics and GynecologyOtaru General HospitalSapporoJapan
  6. 6.Department of Obstetrics and Gynecology, Faculty of Life SciencesKumamoto UniversityKumamotoJapan
  7. 7.Department of Gynecology and ObstetricsKyoto University Graduate School of MedicineKyotoJapan
  8. 8.Department of Obstetrics and GynecologyNiigata University School of MedicineNiigataJapan
  9. 9.Department of Obstetrics and GynecologyKyorin University School of MedicineTokyoJapan
  10. 10.Department of Obstetrics and GynecologyTohoku University Graduate School of MedicineSendaiJapan
  11. 11.Fujita Health University School of MedicineToyoakeJapan
  12. 12.Department of Obstetrics and GynecologyKeio University School of MedicineTokyoJapan

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