International Journal of Clinical Oncology

, Volume 24, Issue 2, pp 153–160 | Cite as

Gestational trophoblastic neoplasia with brain metastasis at initial presentation: a retrospective study

  • Déborah Gavanier
  • Hélène Leport
  • Jérome Massardier
  • Fatima Abbas
  • Anne-Marie Schott
  • Touria Hajri
  • François GolfierEmail author
  • Pierre-Adrien Bolze
Original Article



To evaluate the survival and functional outcome of patients with brain metastasis due to gestational trophoblastic neoplasia (GTN).


A 17-year retrospective study based on case review of women with brain metastasis from GTN identified by the electronic databases held in the French Reference Centre. Primary outcome measure: 5-year overall survival calculated with the Kaplan–Meier method. Secondary outcome measures: causes of death, prognostic factors and functional outcomes.


21 patients had GTN brain metastasis and were treated with multidrug chemotherapy without concomitant whole-brain radiation therapy. Three patients died early (< 4 weeks) of cerebral hemorrhage, 3 died ≥ 1 months after treatment initiation and 15 were alive at the date of last contact. The overall survival rate at 5 years was 69.8% (95% CI 44.3–85.3). After excluding early deaths, the survival rate at 5 years was 81.5% (95% CI 52.3–93.7). No predictive factor of survival was identified. Although 11 of the 12 (92%) surviving patients contacted still reported sequelae, nine of them (75%) had resumed a normal life.


After excluding early deaths, this study implies a high survival rate in patients with brain metastasis from GTN. These results were achieved in the total absence of whole-brain radiotherapy and almost completely without the need for intrathecal methotrexate.


Choriocarcinoma Gestational trophoblastic neoplasia Brain metastases Quality of life 



The authors acknowledge the French Ligue Nationale contre le Cancer and the Institut National du Cancer (INCa), which have recognized the French Centre for Trophoblastic Diseases as a Rare Tumour Centre since 2009 and which renewed funding that enabled this study; the French Centre for Trophoblastic Diseases thanks all the patients who, by giving their signed consent, allowed for this study to be carried out and all the physicians who declared patients because such nationwide epidemiologic studies directly depend on their constructive collaboration.

Compliance with ethical standards

Conflict of interest

The authors report no conflict of interest.


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Copyright information

© Japan Society of Clinical Oncology 2018

Authors and Affiliations

  • Déborah Gavanier
    • 1
  • Hélène Leport
    • 1
  • Jérome Massardier
    • 2
    • 3
  • Fatima Abbas
    • 4
  • Anne-Marie Schott
    • 2
    • 4
  • Touria Hajri
    • 2
  • François Golfier
    • 1
    • 2
    Email author
  • Pierre-Adrien Bolze
    • 1
    • 2
  1. 1.Department of Gynecological Surgery and Oncology, Obstetrics, University of Lyon 1University Hospital Lyon SudPierre-BéniteFrance
  2. 2.French Centre for Trophoblastic DiseasesUniversity Hospital Lyon SudPierre-BéniteFrance
  3. 3.Department of Prenatal DiagnosisUniversity Hospital Femme Mere EnfantBronFrance
  4. 4.Pôle Information Médicale Evaluation Recherche, Equipe d’Accueil 4129Hospices Civils de LyonLyonFrance

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