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Optimal maximum duration for delaying salvage operation when recurrence of retroperitoneal liposarcoma is suspected: a single-center study

  • Jinsoo Rhu
  • Chan Woo Cho
  • Kyo Won Lee
  • Jae Berm Park
  • Sung Joo Kim
Original Article
  • 15 Downloads

Abstract

Background

This study was designed to identify the optimal maximum duration for delaying salvage operation when recurrence of retroperitoneal liposarcoma (LPS) is suspected.

Methods

Patients who underwent salvage operation at Samsung Medical Center for recurrent retroperitoneal LPS from January 2000 to December 2015 were reviewed. The time interval between recurrence and operation for recurrence was divided by 1, 2 or 3 months. A Cox proportional-hazards model was used to analyze factors related to disease-free survival along with recurrence-to-operation interval divided by 1, 2 or 3 months.

Results

The 1-, 3-, and 5-year disease-free survival rates were 43.2%, 15.6% and 13.4%, respectively. FNCLCC grade (p = 0.023) and recurrence-to-operation interval divided by 3 months (p = 0.003) were significant factors associated with recurrence. FNCLCC grade 2 (HR 1.940, CI 0.935–4.026, p = 0.238) and grade 3 (HR 4.049, CI 1.767–9.281, p = 0.007) showed increased risk compared to grade 1. Patients who underwent salvage operation more than 3 months after recurrence showed significantly increased risk of recurrence compared to patients within 3 months (HR 2.724, CI 1.391–5.337, p = 0.003).

Conclusions

Based on our analysis of recurrence-free survival, salvage operation can be delayed for less than 3 months when recurrence is suspected. A short-term follow-up imaging study should be performed within this period.

Keywords

Retroperitoneal liposarcoma Retroperitoneal soft tissue sarcoma Recurrent retroperitoneal liposarcoma 

Abbreviations

LPS

Liposarcoma

STS

Soft tissue sarcoma

CT

Computed tomography

RT

Radiotherapy

FNCLCC

Fédération Nationale des Centres de Lutte Contre le Cancer

Notes

Compliance with ethical standards

Conflict of interest

This authors have no conflict of interest related to this study.

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Copyright information

© Japan Society of Clinical Oncology 2019

Authors and Affiliations

  1. 1.Department of Surgery, Samsung Medical CenterSungkyunkwan University School of MedicineSeoulSouth Korea
  2. 2.Department of SurgeryYeungnam University College of MedicineDaeguSouth Korea

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