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Gastric Cancer

, Volume 21, Issue 6, pp 988–997 | Cite as

Diagnostic accuracy of demarcation using magnifying endoscopy with narrow-band imaging for Helicobacter pylori-uninfected undifferentiated-type early gastric cancer

  • Yusuke Horiuchi
  • Junko Fujisaki
  • Noriko Yamamoto
  • Shoichi Yoshimizu
  • Akiyoshi Ishiyama
  • Toshiyuki Yoshio
  • Toshiaki Hirasawa
  • Yorimasa Yamamoto
  • Masatsugu Nagahama
  • Hiroshi Takahashi
  • Tomohiro Tsuchida
Original Article
  • 357 Downloads

Abstract

Background

It is unknown how the accuracy rate of diagnostic demarcation of undifferentiated-type early gastric cancers (UD-type EGCs) differs between patients uninfected with Helicobacter pylori (H. pylori) and patients with and without H. pylori eradication. This study assessed and compared the diagnostic accuracy rate in the H. pylori-uninfected group and the non-H. pylori eradication and H. pylori eradication groups.

Methods

Subjects were 81 patients with 81 lesions who underwent endoscopic submucosal dissection between January 2010 and January 2015. There were 21 lesions in the H. pylori-uninfected group, 27 in the H. pylori eradication group, and 33 in the non-H. pylori eradication group. The rate in the H. pylori-uninfected group was separately compared with the rates in the non-H. pylori eradication and H. pylori eradication groups, as was inflammatory cell infiltration.

Results

The diagnostic accuracy rates were 60.6% in the non-H. pylori eradication group, 92.2% in the H. pylori eradication group, and 100% in the H. pylori-uninfected group; the rate was significantly higher in the H. pylori-uninfected group than in the non-H. pylori eradication group, but no significant difference was observed between the H. pylori-uninfected group and the H. pylori eradication group. In addition, the H. pylori-uninfected and H. pylori eradication groups showed no significant differences in neutrophil infiltration and intestinal metaplasia, whereas the state in the H. pylori-uninfected group was significantly milder.

Conclusions

Because neutrophil infiltration was classified as mild or none, the accuracy of diagnostic demarcation was high in the H. pylori-uninfected and H. pylori eradication groups.

Keywords

Gastric cancer Endoscopic resection Helicobacter pylori Endoscopic gastrointestinal surgery 

Notes

Compliance with ethical standards

Conflict of interest

There is no conflict of interest in this study.

Human rights statement and informed consent

This study was conducted in compliance with the principles of the “Declaration of Helsinki” issued in 1964 and revised thereafter. Prior to registration, all personal identifiers were deleted and informed consent was obtained from all patients to allow the use of pathological specimens and imaging data for this study.

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Copyright information

© The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2018

Authors and Affiliations

  • Yusuke Horiuchi
    • 1
  • Junko Fujisaki
    • 1
  • Noriko Yamamoto
    • 2
  • Shoichi Yoshimizu
    • 1
  • Akiyoshi Ishiyama
    • 1
  • Toshiyuki Yoshio
    • 1
  • Toshiaki Hirasawa
    • 1
  • Yorimasa Yamamoto
    • 3
  • Masatsugu Nagahama
    • 3
  • Hiroshi Takahashi
    • 3
  • Tomohiro Tsuchida
    • 1
  1. 1.Department of GastroenterologyCancer Institute HospitalTokyoJapan
  2. 2.Department of PathologyCancer Institute HospitalTokyoJapan
  3. 3.Department of GastroenterologyShowa University Fujigaoka HospitalYokohamaJapan

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