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Gastric Cancer

, Volume 22, Issue 1, pp 123–129 | Cite as

Validation of the prognostic impact of the new tumor-node-metastasis clinical staging in patients with gastric cancer

  • Etsuro Bando
  • Rie Makuuchi
  • Tomoyuki Irino
  • Yutaka Tanizawa
  • Taiichi Kawamura
  • Masanori Terashima
Original Article

Abstract

Background

In the 8th edition of the tumor-node-metastasis (TNM) classification, the gastric cancer staging system includes two classifications: the clinical stage (cStage) and the postoperative pathologic stage. However, the correlation between the new cStage and overall survival has not been studied. Moreover, clinical N (cN) grade analysis is not included in the new clinical staging system. This study validated the prognostic value of cStage in the 8th edition of the TNM classification and the significance of N classification for pretreatment staging in gastric cancer.

Methods

A total of 4374 patients with primary gastric cancer who underwent surgery at the Shizuoka Cancer Center were included. Survival analysis was conducted based on the newly proposed cStage criteria of the TNM 8th edition. Prognostic accuracy was evaluated using Harrell’s concordance index (C-index).

Results

The five-year survival rates according to cStage were as follows: cStageI, 91.2%, cStageIIA: 75.1%, cStageIIB: 57.7%, cStageIII: 43.2%, cStageIVA: 31.6%, and cStageIVB: 7.7%. Significant differences were observed among all stages (P < 0.001). The cStage C-index was 0.802. Meanwhile, the five-year survival rates based on cN were as follows: cN0: 83.7%, cN1: 57.2%, cN2: 42.4%, cN3a: 22.1%, and cN3b: 0.0%. Significant differences were also observed among all cN grades (P < 0.001).

Conclusions

The cStage of the 8th edition of the TNM classification has a good capability to predict prognosis; thus, it may be a useful indicator for selecting appropriate gastric cancer treatment modalities. In addition, cN can be included in developing a more precise clinical staging of gastric cancer.

Keywords

Stomach neoplasms Neoplasm staging Survival 

Notes

Funding

This study was supported in part by a scientific research grant from multi-institutional trials to establish a new standard treatment of solid tumors in adults from the National Cancer Center Research and Development Fund (26-A-4) and Practical Research for Innovative Cancer Control from the Japan Agency for Medical Research and Development, AMED (15ck0106043h0002).

Compliance with ethical standards

Conflicts of Interest

The authors declare that they have no conflict of interest.

Ethical standards

All procedures performed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. Informed consent or an appropriate substitute was obtained from all patients prior to inclusion in the study.

Supplementary material

10120_2018_799_MOESM1_ESM.docx (31 kb)
Supplementary material 1 (DOCX 31 kb)
10120_2018_799_MOESM2_ESM.pptx (398 kb)
Supplementary material 2 (PPTX 398 kb)
10120_2018_799_MOESM3_ESM.docx (30 kb)
Supplementary material 3 (DOCX 30 kb)

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Copyright information

© The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2018

Authors and Affiliations

  1. 1.Division of Gastric SurgeryShizuoka Cancer CenterSuntougunJapan

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