High-power therapeutic ultrasound for treatment of abdominal localized adiposity—double-blind randomized clinical trial

  • Karina da Silva SiqueiraEmail author
  • Joaquim Miguel Maia
Original Article


This study aimed to evaluate the effects of high-power therapeutic ultrasound in the treatment of abdominal localized adiposity in an isolated manner, with the use of neutral gel comparing ultrasonic application with 5% lipolytic active caffeine gel (phonophoresis). A total of 90 healthy women aged between 18 and 40 years were randomized and divided into two groups. The volunteers underwent anamnesis evaluation, perimetry, bioimpedance, ultrasound examination, and blood tests (complete lipidogram, creatinine, and vitamin D) before and after the end of the 10-session ultrasound protocol (3 MHz, 2 W/cm2, and 30w). Comparisons between groups and pre-post evaluation were performed by a two-way repeated-measures analysis of variance. Values of p < 0.05 indicated statistical significance. The results demonstrated a significant reduction in both groups, for the perimetry (p < 0.001) and measurements of adipose tissue thickness (p < 0.001). The examinations exhibited a significant alteration only of the complete lipidogram, but without significance (p > 0.05). When comparing the groups, no statistically significant difference was identified in any of the analyzed parameters. The high-power ultrasonic therapy is efficient in reducing localized adiposity, regardless of whether it is applied with neutral gel or 5% caffeine gel.


Therapeutic ultrasound Phonophoresis High-power Localized adiposity Lipocavitation 


Funding information

Financial support was received from the Brazilian Coordination for the Improvement of Higher Education Personnel (CAPES), the National Council for Scientific and Technological Development (CNPq, No. 306508/2015-0), the Brazilian Study and Project Funding Agency (FINEP, No. 2613/2009), the Araucária Foundation (No. 05/2011-10404), and the Brazilian Ministry of Health (No. 2210/2008).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study was approved by the Research Ethics Committee (CEP) of the Federal University of Technology—Paraná (UTFPR) via Plataforma Brasil, Protocol No. 1956753 of March 9, 2017, in accordance with resolution 466/2012 of the National Health Council.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2019

Authors and Affiliations

  1. 1.Graduate Program in Electrical and Computer Engineering (CPGEI)Federal University of Technology Paraná (UTFPR)CuritibaBrazil
  2. 2.Electronics Engineering Department (DAELN) and Graduate Program in Electrical and Computer Engineering (CPGEI)Federal University of Technology Paraná (UTFPR)CuritibaBrazil

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