Lasers in Medical Science

, Volume 34, Issue 9, pp 1873–1880 | Cite as

Fractional carbon dioxide laser and topical tioconazole in the treatment of fingernail onychomycosis

  • Rania Ahmed El-Tatawy
  • Heba Ahmed Aliweh
  • Doaa Salah HegabEmail author
  • Raghda Ahmed Zaki Talaat
  • Maii Atef Shams Eldeen
Original Article


Onychomycosis is a common chronic-resistant nail disease. Traditional treatment has its limitations and side effects. This study aimed to evaluate the role of fractional CO2 laser and topical tioconazole 28% nail lacquer in the treatment of fingernail onychomycosis, as sole treatment modalities and in combination. Thirty patients with culture-proven onychomycosis were included and randomly divided into three equal groups. Laser group received six fractional carbon dioxide (CO2) laser sessions at monthly intervals; topical group received topical tioconazole 28% nail lacquer twice daily for 6 months, and combined group received six fractional CO2 laser sessions at monthly intervals with topical tioconazole twice daily for 6 months. Treatment outcome was evaluated through physician’s evaluation of improvement using onychomycosis severity index score (OSI), patients’ satisfaction, side effect evaluation, and mycological culture (assessed after the end of treatment). At the end of treatment, both laser and combined groups showed significantly better degrees of improvement (P = 0.036, 0.024, respectively) and patient’s satisfaction (P = 0.046, 0.003, respectively) in comparison with topical group. Mycological clearance in fungal cultures was significantly higher in combined group than topical group after the end of treatment (P = 0.007). Fractional CO2 laser is a safe and effective treatment modality for onychomycosis. Its efficacy approximates that of fractional CO2 laser combined with topical tioconazole 28% nail lacquer and surpasses that of topical tioconazole 28% monotherapy. It is expected to be an excellent choice for patients in whom systemic antifungals are contraindicated or who are unresponsive or intolerant to topical antifungals.


Fractional Co2 laser Onychomycosis Tioconazole Topical 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2019

Authors and Affiliations

  • Rania Ahmed El-Tatawy
    • 1
  • Heba Ahmed Aliweh
    • 1
  • Doaa Salah Hegab
    • 1
    • 2
    Email author
  • Raghda Ahmed Zaki Talaat
    • 3
  • Maii Atef Shams Eldeen
    • 3
  1. 1.Dermatology and Venereology Department, Faculty of MedicineTanta UniversityTantaEgypt
  2. 2.Faculty of Medicine, Dermatology and Venereology DepartmentTanta University HospitalsTantaEgypt
  3. 3.Medical Microbiology and Immunology Department, Faculty of MedicineTanta UniversityTantaEgypt

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