Lasers in Medical Science

, Volume 34, Issue 7, pp 1449–1455 | Cite as

The skin rejuvenation associated treatment—Fraxel laser, Microbotox, and low G prime hyaluronic acid: preliminary results

  • Dario Bertossi
  • Giorgio GiampaoliEmail author
  • Alessandra Lucchese
  • Maurizio Manuelli
  • Massimo Albanese
  • Riccardo Nocini
  • Pier Francesco Nocini
Original Article


Minimally invasive facial rejuvenation procedures reached an all-time high in the 2016. This reveals a growing interest in a smoother, younger, and tighter look accessible using the esthetic medicine tools like botulinum toxin and dermal filler injections, laser, and microdermabrasion. Forty-five patients from 35 to 52 years old (medium age 43.8), 38 women and 7 men underwent 5 sessions of Fraxel laser, 1 session of very low G prime HA, and Microbotox injection treatments from January 2016 and January 2017, were included in this study. In this study, we demonstrated that the usage of three treatments together, like mBTX, Volite, and Fractional laser, have a better result despite every single technique alone. The clinical result showed 98% (44 patients, 6 males, 38 females) of the patients had a smoother skin surface, brighter, more hydrated, and elastic skin; 68% of our patients (31 patients, 5 males, 26 females) showed less skin defects and staining as well as less small wrinkles, thanks to Fraxel laser treatment; 98% (44 patients, 6 males, 38 females) showed tighter skin with less sebaceous gland secretion. The aim of this study was to demonstrate that the combination of three techniques acts better and faster than single treatment to contrast facial aging and to improve skin texture and quality.


Fraxel Microbotox Very low G prime hyaluronic acid 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.


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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Oral and Maxillofacial SurgeryUniversity of VeronaVeronaItaly
  2. 2.Department of OrthodonticsVita-Salute San Raffaele UniversityMilanItaly
  3. 3.Unit of Dentistry, Division of Orthodontics, Research area in Dentofacial Orthopedics and OrthodonticsIRCCS San Raffaele Scientific InstituteMilanItaly
  4. 4.ENT DepartmentUniversity of VeronaVeronaItaly

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