Comparative study on laser and LED influence on tissue repair and improvement of neuropathic symptoms during the treatment of diabetic ulcers
- 16 Downloads
To compare the influence of laser and LED on tissue repair and neuropathic symptoms during treatment of diabetic foot. An intervention survey conducted in a health center located in Brazil, contemplating ten sessions, twice a week, with randomization in two groups. In one group, the wounds were treated with GaAlAs laser, with a wavelength of 830 nm, 30 mW, and power density 0.84 W/cm2, the other group by LED 850 nm, 48 mW, and power density 1.05 W/cm2. For the analysis of wound size, photographic records analyzed by the ImageJ® software were used, and the neuropathy evaluation card examined. With regard to the laser group, a reduction in wound extension of 79.43% was observed at the end of the 10th session; the patients in the LED group had a 55.84% decrease in the healing process; comparing the two therapies was observed a better healing in the participants of the laser group, with 81.17%, in relation to the LED after the end of the sessions; regarding the evaluation of the neuropathic condition, there was a significant improvement in both therapies. There was improvement of the neuropathic signs and symptoms, also improvement of the tissue repair in the two therapeutic modalities; however, the laser presented a higher rate of speed in relation to the LED.
KeywordsDiabetes mellitus Ulcers Phototherapy Lasers
Compliance with ethical standards
All procedures performed in this study, involving human participants, were in accordance with the ethical standards of the Ethics and Research Committee on Human Studies of the Federal University of Ceará (number 1.817.533).
Conflict of interest
The authors declare that they have no conflict of interest.
- 1.2017) Promoting Health and Reducing Disparities in Populations [editorial]. Journal of clinical and applied research and education diabetes care 40 (suppl 1): 6–10. doi: https://doi.org/10.2337/dc17-S004
- 2.Ministry of Health (BR) (2016) Diabetic foot manual: a strategy for the care of the person with chronic disease. Ministry of Health, BrasíliaGoogle Scholar
- 3.(2017) Evaluation and treatment of patients with neuropathy: pain and autonomic neuropathy [editorial]. Guidelines of the Brazilian Society of Diabetes. São Paulo: Clannad. p. 291–299Google Scholar
- 5.Tatmatsu Rocha JC, Ferraresi C, Hamblin MR, Damascene FM, Birth NRF, Driusso P et al (2016) Low-level laser therapy (904 nm) can increase collagen and reduce oxidative and nitrosative stress in diabetic wounded mouse skin. J Photochem Photobiol 164:96–102. https://doi.org/10.1016/j.jphotobiol.2016.09.017 CrossRefGoogle Scholar
- 6.Steiger S; Veprek RG.; Witzigmann B Unified modelling of electro luminescence in nano structures. 9th International Conference on Numerical Simulation of Opto Electronic Devices. September/2009; p.73–74. doi:10.1109/NUSOD.2009.5297218Google Scholar
- 9.Schubert EF (2018) Light-emitting diodes. E. Fred SchubertGoogle Scholar
- 12.Brazil. Ministry of Health. Resolution no. 466, of December 12, 2012. Guidelines and Norms Regulating Research involving human beings. Official Gazette of the Federative Republic of Brazil. 2012 dez. 12; Section 1. P. 5Google Scholar
- 13.Haslbeck M, Luft D, Neundorfer B, Stracke H, Ziegler D (2004) Diagnosis, treatment and follow-up of diabetic neuropathy. 2. ed. German Diabetes Association, GermanyGoogle Scholar
- 16.Tatmatsu-Rocha JC, Tim CR, Avo L, Bernardes Filho R, Brassolati P, Kido HW, Parizotto NA (2018) Mitochondrial dynamics (fission and fusion) and collagen production in a rat model of diabetic wound healing treated by photobiomodulation: comparison of 904 nm laser and 850 nm light-emitting diode (LED). J Photochem Photobiol B Biol 187:41–47. https://doi.org/10.1016/j.jphotobiol.2018.07.032 CrossRefGoogle Scholar
- 18.Epidemiology and Prevention [editorial]. Guidelines of the Brazilian Society of Diabetes. Rio de Janeiro: AC Pharmaceuticals; 2016. P. 3–6Google Scholar
- 22.Moura RO, Nunes LCC, Carvalho MEIM, Miranda BR (2014) Effects of light emitted by diodes (LED) and chitosan compounds on wound healing systematic review. J Appl Basic Pharmaceut Sci 35(4):513–518Google Scholar
- 23.Agnol MAD, Nicolau A, Lima CJ, Munin E Comparative analysis of coherent light action (laser) versus non-coherent light (light-emitting diode) for tissue repair in diabetic rats. Laser Med Sci 200(2):909–916. https://doi.org/10.1007/s10103-009-0648-5
- 24.Chaves MEA, Araújo AR, Piancastelli ACC, Pinotti M (2014) Effects of low power light therapy on wound healing: LASER x LED. In: Anais Brasileiros de Dermatologia, Rio de Janeiro. Rio de Janeiro: Brazilian Society of Dermatology. 89 (4): 616–623. https://doi.org/10.1590/abd1806-4841.20142519
- 26.Ferraresi C, Dos Santos RV, Marques G, Zangrande M, Leonaldo R, Hamblin MR et al (2015) Light-emitting diode therapy (LEDT) before matches prevents increase in creatine kinase with a light dose response in volleyball players. Lasers Med Sci 30(4):1281–1287. https://doi.org/10.1007/s10103-015-1728-3 CrossRefGoogle Scholar