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Efficacy of laser surgery versus radiotherapy for treatment of glottic carcinoma: a systematic review and meta-analysis

  • Yongxia Ding
  • Binquan Wang
Original Article
  • 15 Downloads

Abstract

Laser surgery and radiotherapy are the two most common ways to treat glottic carcinomas, which is more efficacious and remains controversial. PubMed, Embase, and Cochrane Library were searched to identify relevant studies of laser surgery versus radiotherapy in patients with glottic carcinomas through April 2017. Sensitivity analysis and subgroup analysis were performed to evaluate heterogeneity. Eighteen studies were selected, which included 2480 patients. Patients who had laser surgery had higher rates of laryngeal preservation (OR 3.852; 95% CI 1.922–7.721) and overall survival (OR 1.388; 95% CI 1.063–1.811) versus who had radiotherapy. No significant differences were observed between laser surgery and radiotherapy on local control (OR 1.186; 95% CI 0.759–1.854), recurrence (OR 0.758; 95% CI 0.445–1.289), or disease-specific survival (OR 1.597; 95% CI 0.887–2.876). There were clinical benefits for patients with glottic carcinoma after laser surgery compared with radiotherapy with respect to survival and laryngeal preservation.

Keywords

Glottic carcinoma Laryngeal preservation Laser surgery Meta-analysis Radiotherapy Recurrence Systematic review 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Not applicable.

Supplementary material

10103_2018_2695_Fig6_ESM.png (275 kb)
Supplementary Fig. 1

Effect of laser surgery on recurrence compared to radiotherapy. (PNG 275 kb)

10103_2018_2695_MOESM1_ESM.tif (240 kb)
High-resolution image (TIF 240 kb)
10103_2018_2695_Fig7_ESM.png (825 kb)
Supplementary Fig. 2

Sensitivity analysis of the meta-analysis. a Overall survival, b disease-specific survival, c laryngeal preservation, d local control, and e recurrence. (PNG 825 kb)

10103_2018_2695_MOESM2_ESM.tif (828 kb)
High-resolution image (TIF 827 kb)
10103_2018_2695_Fig8_ESM.png (391 kb)
Supplementary Fig. 3

Funnel plots of the meta-analysis. a Overall survival, b disease-specific survival, c laryngeal preservation, d local control, and e recurrence. (PNG 391 kb)

10103_2018_2695_MOESM3_ESM.tif (387 kb)
High-resolution image (TIF 386 kb)

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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Nursing College of Shanxi Medical UniversityTaiyuanPeople’s Republic of China
  2. 2.Shanxi Key Laboratory of Otolaryngology, Head and Neck CancerTaiyuanPeople’s Republic of China
  3. 3.Department of Otolaryngology, Head and Neck Surgery, The First HospitalShanxi Medical UniversityTaiyuanPeople’s Republic of China

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