Lasers in Medical Science

, Volume 33, Issue 9, pp 1841–1848 | Cite as

Photobiomodulation on critical bone defects of rat calvaria: a systematic review

  • Patricia BrassolattiEmail author
  • Ana Laura Martins de Andrade
  • Paulo Sérgio Bossini
  • Daiana Laurenci Orth
  • Fernanda Oliveira Duarte
  • Ana Beatriz dos Anjos Souza
  • Nivaldo Antonio Parizotto
  • Fernanda de Freitas Anibal
Review Article


Bone defects following trauma represent a high impact on the quality of life of millions of people around the world. The aim of this study was to review photobiomodulation (PBM) action in the treatment of bone critical defects in rat calvaria, related to evaluation of the current protocols applied. One hundred and forty-seven articles related to the subject were found by searching the main databases (Pubmed, Lilacs, Web of Science, and Scopus) considering the period of publication until the year 2017, and only 14 corresponded the inclusion criteria established for this systematic review. The main parameters of the PBM were expressed in Table 1. In addition, it was possible to observe the use of two different wavelengths (red and infrared), which are considered therapeutic. Most of the evaluated articles presented positive results that describe a greater amount of neoformed bone, an increase in collagen synthesis, and a contribution to microvascular reestablishment. However, two studies report no effect on the repair process when the PBM was used. In addition, we observed considerable variations between the values of power, fluence, and total energy, which make it difficult to compare the results presented between the selected studies. It was possible to conclude that the infrared laser was more effective in positively stimulating the bone repair process of critical defects. Furthermore, a discrepancy was found in the parameter values used, which made it difficult to choose the best protocol for the treatment of this type of lesion.


Bone Critical bone defects Photobiomodulation 


Funding source

This work is financially supported by the CAPES National Postdoctoral Program (PNPD/CAPES).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2018

Authors and Affiliations

  • Patricia Brassolatti
    • 1
    • 2
    Email author
  • Ana Laura Martins de Andrade
    • 3
  • Paulo Sérgio Bossini
    • 2
  • Daiana Laurenci Orth
    • 4
  • Fernanda Oliveira Duarte
    • 5
  • Ana Beatriz dos Anjos Souza
    • 1
  • Nivaldo Antonio Parizotto
    • 3
  • Fernanda de Freitas Anibal
    • 1
  1. 1.Department of Morphology and Pathology, Post-Graduate Program in Evolutionary Genetics and Molecular BiologyFederal University of São Carlos (UFSCar)Sao CarlosBrazil
  2. 2.Research and Education Center for Phototherapy in Health Sciences (NUPEN)Sao CarlosBrazil
  3. 3.Department of Physiotherapy, Post-Graduate Program of PhysiotherapyFederal University of São Carlos (UFSCar)Sao CarlosBrazil
  4. 4.Post-Graduate Program of BiotechnologyFederal University of São Carlos (UFSCar)Sao CarlosBrazil
  5. 5.Department of Electrical and Computer Engineering, Ophthalmic Instrumentation LaboratoryEngineering School of São Carlos (USP)Sao CarlosBrazil

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