Lasers in Medical Science

, Volume 34, Issue 3, pp 637–648 | Cite as

Effects and parameters of the photobiomodulation in experimental models of third-degree burn: systematic review

  • Carlos Alberto Ocon
  • Solange Almeida dos Santos
  • Jheniphe Rocha Caires
  • Marcelo Ferreira Duarte de Oliveira
  • Andrey Jorge Serra
  • Ernesto Cesar Leal-Junior
  • Paulo de Tarso Camillo de CarvalhoEmail author
Original Article


This systematic review was performed to identify the role of photobiomodulation therapy in experimental models of third-degree burns used to induce oxidative stress. EMBASE, PubMed, and CINAHL databases were searched for studies published between January 2003 and January 2018 on the topics of photobiomodulation therapy and third-degree burns. Any study that assessed the effects of photobiomodulation therapy in animal models of third-degree burns was included in the analysis. A total of 17 studies were selected from 1182 original articles targeted on photobiomodulation therapy and third-degree burns. Two independent raters with a structured tool for rating the research quality critically assessed the articles. Although the small number of studies limits the conclusions, the current literature research indicates that photobiomodulation therapy can be an effective short-term approach to accelerate the healing process of third-degree burns, to increase and modulate the inflammatory process, to accelerate the proliferation of fibroblasts, and to enhance the quality of the collagen network. However, differences still exist in the terminology used to describe the parameters and the dose of photobiomodulation therapy.


Photobiomodulation therapy Wound healing Burns 


Role of the funding source

This work was supported by grants from the São Paulo Research Foundation (FAPESP, grant number (2015/13677-4) and the National Council for Scientific and Technological (grant number 309065/2015-1).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2018

Authors and Affiliations

  • Carlos Alberto Ocon
    • 1
  • Solange Almeida dos Santos
    • 2
  • Jheniphe Rocha Caires
    • 2
  • Marcelo Ferreira Duarte de Oliveira
    • 1
  • Andrey Jorge Serra
    • 1
  • Ernesto Cesar Leal-Junior
    • 2
  • Paulo de Tarso Camillo de Carvalho
    • 1
    • 2
    Email author
  1. 1.Postgraduate Program in Biophotonics Applied to Health SciencesUniversidade Nove de Julho (UNINOVE)São PauloBrazil
  2. 2.Postgraduate Program in Rehabilitation SciencesUniversidade Nove de Julho (UNINOVE)São PauloBrazil

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