Lasers in Medical Science

, Volume 34, Issue 3, pp 555–559 | Cite as

Blue laser imaging with acetic acid enhancement improved the detection rate of gastric intestinal metaplasia

  • Honglei ChenEmail author
  • Xiaobin Wu
  • Yanan Liu
  • Qiuning Wu
  • Yi Lu
  • Chujun LiEmail author
Original Article


Our aim was to evaluate the ability of blue laser imaging (BLI) combined with acetic acid (BLI-AA) to detect gastric intestinal metaplasia (GIM). Participants undergoing gastroscopy from July 2017 to February 2018 in our hospital were enrolled prospectively. The abilities of white light imaging endoscopy, BLI endoscopy, and BLI-AA to detect GIM were compared. One hundred six patients undergoing gastroscopy met the inclusion criteria. GIM was diagnosed in 41 patients. For BLI-AA, the sensitivity, specificity, positive predictive, and negative predictive values were 85.4%, 84.6%, 77.8%, and 90.2% respectively. The diagnostic accuracy rate for BLI-AA was 84.9%, which was higher than that of white light imaging endoscopy and BLI endoscopy. For target biopsy, the GIM detection rate for the BLI-AA mode was significantly higher (77.8%, 105/135) than that for the BLI mode (58.3%, 84/144) or the white light endoscopy mode (40.4%, 57/141) (p < 0.05). BLI-AA is an efficient and simple method for the detection of GIM.


Acetic acid Intestinal metaplasia Blue laser imaging Detection 


Funding information

This study was supported by the National Key Clinical Discipline and Guangdong Institute of Gastroenterology.

Compliance with ethical standards

Written informed consent was obtained from all participants. This study, which was approved by the Ethics Committee of the Sixth Affiliated Hospital of Sun Yat-sen University, was registered in the Chinese Clinical Trial Registry (ChiCTR-DDD-17011370) and conducted following the Declaration of Helsinki.

Conflict of interest

Honglei Chen has received funding from Guangdong province medical science and technology research fund project (grant number: A2017273). For the remaining authors, none were declared.


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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Gastrointestinal Endoscopy, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouPeople’s Republic of China
  2. 2.Department of Gastrointestinal Surgery, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouPeople’s Republic of China

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