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Limited awareness of the effective timing of HIV post-exposure prophylaxis among people with high-risk exposure to HIV

  • Daniel LeshinEmail author
  • Karen Olshtain-Pops
  • Allon Moses
  • Hila Elinav
Original Article

Abstract

The effectiveness of post-exposure prophylaxis (PEP), a major strategy in the battle against HIV, depends on awareness of this modality and its proper timing among high-risk groups. While general awareness of PEP is improving, recently estimated to be 36–47% among men who have sex with men (MSM), PEP implementation remains disappointingly low and may be driven by limited awareness of effective PEP timing window. The level of detailed understanding of PEP timing and effectiveness among populations at risk has not been prospectively assessed to date. We prospectively evaluated, for the first time, actionable awareness regarding effective timing of PEP among a large cohort of individuals tested for HIV following unprotected sexual intercourse. Four hundred participants were assessed between December 2014 and February 2016. Overall awareness of the option of PEP was 60% and was significantly higher among male members of the LGBTQ community (75·5% as compared to 52·6% among heterosexual males) and those undergoing past HIV testing (67·1%). However, only 24% of individuals at risk were aware as to the proper timing of effective PEP treatment, thereby leading, in the majority of cases, to missing the window of opportunity for PEP treatment. This study highlights the lack of knowledge as to the specific requirements needed for effective PEP timing. Expanded advertising, better targeting of the heterosexual population, training of family physicians in the field of gender, sexuality, and LGBTQ medicine, may improve effective PEP availability, thereby reducing HIV transmission.

Keywords

HIV Post-exposure prophylaxis Awareness 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study was approved by the IRB committee of Hadassah-Hebrew University Medical Center.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

10096_2019_3476_MOESM1_ESM.docx (15 kb)
ESM 1 (DOCX 14 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Internal Medicine AAssuta Ashdod HospitalAshdodIsrael
  2. 2.Hadassah AIDS Center, Clinical Microbiology and Infectious Diseases DepartmentHadassah-Hebrew University Medical CenterJerusalemIsrael

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