Evaluation of IVD 3.0 Vitek MS matrix-assisted laser desorption ionization-time of flight mass spectrometry for identification of Mycobacterium tuberculosis and nontuberculous mycobacteria and its use in routine diagnostics
Rapid and accurate identification of Mycobacterium tuberculosis (MT) and nontuberculous mycobacteria (NTM) is essential for diagnosis, appropriate therapy, and infection control. Nevertheless, identification by conventional methods is a labor-intensive and time-consuming process, particularly for NTM .
Matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry (MS), widely used for identification of bacteria and yeasts [2, 3], has been applied also to mycobacteria [4, 5, 6]. Recent studies evaluated the performance of the new CE-IVD released IVD 3.0 Vitek MS (bioMérieux, Marcy l’Etoile, France) for the identification of MT and NTM isolates from strain collections  or from positive cultures of clinical specimens [8, 9], demonstrating its utility in clinical practice in different geographic areas. To our knowledge, no data on the use of this system are reported from Italian laboratories, including the impact on time to report after its...
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