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Relevance of genetically determined host factors to the prognosis of meningococcal disease

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Abstract

To assess the relevance of genetically determined host factors for the prognosis of meningococcal disease, Fc gamma receptor IIA (FcγRIIA), the tumor necrosis factor alpha (TNF-α) gene promoter region, and plasminogen-activator-inhibitor-1 (PAI-1) gene polymorphisms were studied in 145 patients with meningococcal disease and in 290 healthy controls matched by sex. Distribution of FcγRIIA, TNF-α, and PAI-1 alleles was not significantly different between patients and controls. Patients with the FcγRIIA-R/R 131 allotype scored ≥1 point in the Barcelona prognostic system more frequently than patients with other allotypes (odds ratio, 18.6; 95% confidence interval, 7.1–49.0, P<0.0001), and they had a higher risk of sequelae (odds ratio, 3.5; 95% confidence interval, 1.1–11.7; P=0.03). Fc gamma receptor IIA polymorphism was associated with markers of disease severity, but TNF-α and PAI-1 polymorphisms were not.

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Acknowledgments

This study was supported by grants from the Fondo de Investigaciones Sanitarias (FIS) (No. 97/0834-01) and from the Instituto Científico Roussel. Support was also provided by the Red de Investigación de Patología Infecciosa (REIPI) from the Ministerio de Sanidad y Consumo, Spain.

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Authors and Affiliations

  1. Infectious Diseases Unit, Department of Internal Medicine, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Avenida Sant Antoni Ma. Claret 167, 08025, Barcelona, Spain

    P. Domingo, M. A. Baraldès, N. Barquet & G. Vázquez

  2. Department of Hematology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Avenida Sant Antoni Ma. Claret 167, 08025, Barcelona, Spain

    E. Muñiz-Diaz, M. Arilla & P. Madoz

  3. Department of Microbiology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Avenida Sant Antoni Ma. Claret 167, 08025, Barcelona, Spain

    R. Pericas

  4. Department of Immunology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Avenida Sant Antoni Ma. Claret 167, 08025, Barcelona, Spain

    C. Juárez

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  1. P. Domingo
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  2. E. Muñiz-Diaz
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  3. M. A. Baraldès
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  4. M. Arilla
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  5. N. Barquet
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  6. R. Pericas
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  7. C. Juárez
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  8. P. Madoz
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  9. G. Vázquez
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Correspondence to P. Domingo.

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Domingo, P., Muñiz-Diaz, E., Baraldès, M.A. et al. Relevance of genetically determined host factors to the prognosis of meningococcal disease. Eur J Clin Microbiol Infect Dis 23, 634–637 (2004). https://doi.org/10.1007/s10096-004-1167-8

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