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Neurological Sciences

, Volume 22, Issue 6, pp 429–435 | Cite as

The role of NCAM in remyelination

  • A. R. Massaro
REVIEW

Abstract

The neural cell adhesion molecule (NCAM) is expressed by myelinating precursor cells in neonatal mouse spinal cord and by remyelinating cells after chemically induced demyelination in adult mouse. It shows tempting suggestions about its possible involvement in the reparative mechanisms and the remyelination processes that take place in multiple sclerosis (MS). In fact, its levels progressively increase in the cerebrospinal fluid (CSF) of acute MS patients subjected to steroid treatment, paralleling the progressive clinical improvement after the attack. Such an increase is not found in nacute MS patients not treated with steroids nor in non-acute patients subjected to the same steroid treatment.

Key words NCAM PSA-NCAM Myelination Remyelination Multiple sclerosis Steroid Cerebrospinal fluid 

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Copyright information

© Springer-Verlag Italia 2002

Authors and Affiliations

  • A. R. Massaro
    • 1
  1. 1.Institute of Neurology, UCSC Medical School, Largo Gemelli 8, I-00168 Rome, ItalyIT

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