Peculiar EEG signatures, ictal drinking and long-term follow-up in anti-LGI1 encephalitis

  • Alberto VogrigEmail author
  • Giada Pauletto
  • Christian Lettieri
  • Mariarosaria Valente
  • Gian Luigi Gigli
Letter to the Editor

Dear Editor,

The diagnosis of autoimmune encephalitis relies on clinical, radiological, and laboratory criteria [1]. Neither the clinical presentation nor the neuroimaging studies are able to effectively discriminate between different antibody-mediated syndromes. Antibody testing—the only way to confirm the diagnosis and to detect the pathogenic antibody—is not readily accessible in many institutions, and result may require several weeks to be obtained [1]. On the contrary, electroencephalography (EEG) is a safe, inexpensive, and often informative diagnostic tool. Historically, EEG has had limited utility in the diagnosis of autoimmune encephalitis because only non-specific EEG patterns were described. Only recently, it was demonstrated that certain EEG findings might have a guiding role in request for antibody testing, as the case of the extreme delta brush pattern in anti-NMDA receptor (NMDAR) encephalitis [1]. It is now generally accepted that “faciobrachial dystonic seizures”...


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


The corresponding author had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Ethical standard

The patient’s consent was obtained for publication of this case report.

Supplementary material

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Supplementary Figure 2

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High resolution image (TIFF 73622 kb)


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Copyright information

© Fondazione Società Italiana di Neurologia 2019

Authors and Affiliations

  1. 1.Clinical Neurology UnitSanta Maria della Misericordia University HospitalUdineItaly
  2. 2.Centre de Référence des Syndromes Neurologiques Paranéoplasiques et Encéphalites Auto-immunesHôpital Neurologique et Neurochirurgical Pierre WertheimerLyonFrance
  3. 3.Department of NeurosciencesSanta Maria della Misericordia University HospitalUdineItaly
  4. 4.Neurology Unit, Department of Medicine (DAME)University of Udine Medical SchoolUdineItaly

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