Neurological Sciences

, Volume 40, Issue 4, pp 725–731 | Cite as

Evaluation of anxiety and depression scales and quality of LIFE in cervical dystonia patients on botulinum toxin therapy and their relatives

  • Dursun Ceylan
  • Sevda ErerEmail author
  • Mehmet Zarifoğlu
  • Nevin Türkeş
  • Güven Özkaya
Original Article



In this study, quality of life and psychiatric comorbid disorders were investigated in patients with cervical dystonia and their spouses and we also investigated the effect of botulinum toxin (BTX) treatment on these parameters.

Material and method

Thirty patients with cervical dystonia (CD) on BTX treatment and their spouses (n = 30) were included. Beck Depression Scale (BDS), State-Trait Anxiety Inventory I and II (STAI-I, STAI-II), Hospital Anxiety Scale (HAS), Hospital Depression Scale (HDS) for psychiatric comorbid disease assessment, Toronto Western Spasmodic Torticollis Scale (TWSTRS) for disease activity assessment, and Craniocervical Dystonia Questionnaire (CDQ-24), Cervical Dystonia Impact Profile (CDIP-58), and Short Form 36 (SF-36) questionnaires for quality of life assessment were used. BDS, STAI-I and STAI-II, HAS, HDS, and SF-36 scales were also obtained from the spouses. The same tests were applied both before and 8 weeks after the BTX treatment.


In our study, an increase in psychiatric comorbid disorders such as depression and anxiety was observed and the quality of life was adversely affected in all areas in patients. In the spouses of the patients, the rates of psychiatric comorbid disorders such as depression and anxiety were found to be increased when compared to healthy subjects while vitality, mental health, and general health perception were found to be negatively affected.

Patients showed improvements in anxiety level, disease activity, and overall quality of life scales after BTX treatment.


Cervical dystonia Botulinum toxin therapy Quality of life Depression Anxiety 



This research did not receive any grants or funding from any funding agencies. The authors have no funding to report.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Fondazione Società Italiana di Neurologia 2019

Authors and Affiliations

  1. 1.Medical Faculty, Department of Neurology, Department of NeurologyUludag UniversityBursaTurkey
  2. 2.Medical Faculty, Department of BiostatisticsUludag UniversityBursaTurkey

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