SCN11A variant as possible pain generator in sensory axonal neuropathy
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Voltage-gated sodium channel (NaV) Nav1.9 is expressed in dorsal root ganglion and their axons and has been shown to play an important role both in regulating sensory neuron excitability and in pain signaling . Heterozygous missense mutations in the SCN11A gene encoding NaV1.9 have been recently described in individuals with painful peripheral neuropathy . It is thought that enhanced NaV channel activity may directly contribute to the pain because some of the missense variants identified depolarize resting membrane potential of dorsal root ganglion neurons through a gain-of-function mechanism, enhance spontaneous firing, and increase evoked firing of these neurons . A recent report on SCN11A variants influencing postoperative pain sensitivity suggests that Nav1.9 can be considered among the main effectors of peripheral inflammatory and neuropathic pain hypersensitivity [1, 3] and should be regarded as an attractive target while searching more effective treatments...
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The authors declare that they have no conflicts of interest.
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