Restless legs syndrome and its variants: a case report

  • Amée F. WoltersEmail author
  • Bart F. L. van Nuenen
Letter to the Editor

Dear Editor,

Restless legs syndrome (RLS) is a common movement disorder, which affects 2–3% of the adult population [1]. Despite the fact that it has a substantial effect on the quality of life, it is often not recognized and left untreated for years [2]. The disorder is characterized by an urge to move the legs, usually combined with an uncomfortable feeling in the legs. These symptoms occur or worsen during periods of inactivity and are partially or totally relieved by movement [1]. Involvement of other limbs is described in relation to progression of the disease but is rarely described as the presenting symptom.

A 49-year-old male patient was referred to our hospital with symptoms of stabbing pains and restlessness in both arms, mainly present in the evening and during the night, for about 10 years. When the complaints were severe, he felt an urge to move his arms which resulted in a slight relief of the symptoms. He did not experience any symptoms in his legs. He had already...



No specific funding or material support was received for this work.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


  1. 1.
    Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, Winkelman JW, Zucconi M, Ferri R, Trenkwalder C, Lee HB, International Restless Legs Syndrome Study G (2014) Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria--history, rationale, description, and significance. Sleep Med 15(8):860–873. CrossRefPubMedGoogle Scholar
  2. 2.
    Trenkwalder C, Allen R, Hogl B, Clemens S, Patton S, Schormair B, Winkelmann J (2018) Comorbidities, treatment, and pathophysiology in restless legs syndrome. Lancet Neurol 17(11):994–1005. CrossRefPubMedGoogle Scholar
  3. 3.
    Allen RP (2015) Restless leg syndrome/Willis-Ekbom disease pathophysiology. Sleep Med Clin 10(3):207–214, xi. CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Scholz H, Trenkwalder C, Kohnen R, Riemann D, Kriston L, Hornyak M (2011) Dopamine agonists for restless legs syndrome. Cochrane Database Syst Rev 3:CD006009. CrossRefGoogle Scholar
  5. 5.
    Clemens S, Rye D, Hochman S (2006) Restless legs syndrome: revisiting the dopamine hypothesis from the spinal cord perspective. Neurology 67(1):125–130. CrossRefPubMedGoogle Scholar
  6. 6.
    Michaud M, Chabli A, Lavigne G, Montplaisir J (2000) Arm restlessness in patients with restless legs syndrome. Mov Disord 15(2):289–293CrossRefGoogle Scholar
  7. 7.
    Freedom T, Merchut MP (2003) Arm restlessness as the initial symptom in restless legs syndrome. Arch Neurol 60(7):1013–1015. CrossRefPubMedGoogle Scholar
  8. 8.
    Sforza E, Hupin D, Roche F (2017) Restless genital syndrome: differential diagnosis and treatment with pramipexole. J Clin Sleep Med 13(9):1109–1110. CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Prakash S, Ahuja S, Rathod C (2012) Dopa responsive burning mouth syndrome: restless mouth syndrome or oral variant of restless legs syndrome? J Neurol Sci 320(1-2):156–160. CrossRefPubMedGoogle Scholar
  10. 10.
    Turrini A, Raggi A, Calandra-Buonaura G, Martinelli P, Ferri R, Provini F (2018) Not only limbs in atypical restless legs syndrome. Sleep Med Rev 38:50–55. CrossRefPubMedGoogle Scholar

Copyright information

© Fondazione Società Italiana di Neurologia 2019

Authors and Affiliations

  1. 1.Department of NeurologyMaastricht University Medical CentreMaastrichtThe Netherlands
  2. 2.Department of NeurologyCatharina Hospital EindhovenEindhovenThe Netherlands

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