Effect of eccentric-based rehabilitation on hand tremor intensity in Parkinson disease

  • Mona Kadkhodaie
  • Ali SharifnezhadEmail author
  • Safoora Ebadi
  • Sadegh Marzban
  • Seyed Amirhassan Habibi
  • Amin Ghaffari
  • Bijan ForoghEmail author
Original Article


Background and purpose

Hand tremor is a disturbing yet sometimes resistant symptom in persons with Parkinson disease (PD). Although many exercise regimens for these people have gained attention in recent years, the effect of resistance training and especially eccentric training on parkinsonian tremor is still uncertain. This study was conducted to investigate the precise effect of upper limb eccentric training on hand tremor in PD.


In this randomized controlled trial, a consecutive sample of 21 persons with PD recruited from general hospitals went through 6 weeks of upper limb pure eccentric training as the intervention group (n = 11) or no additional exercise during this period as the control group (n = 10). Resting and postural tremor amplitudes were measured with the cellphone-based accelerometer.


Comparing hand tremor amplitudes before and after the trial showed a significant reduction in resting tremor amplitude in the intervention group after exercise sessions (p < 0.05) while detecting no changes in the control group during 6 weeks of study. Meanwhile, postural tremor amplitude remained unchanged in both groups.


Resistance training Resting tremor Parkinson disease Neurorehabilitation 



Parkinson disease


Body mass index


Rate of perceived exertion


Repetition maximum


Discussion and conclusions

Resting hand tremor improvement in response to the training sessions is explainable through possible neuroplasticity effects of exercise. We concluded eccentric exercise is effective in resting hand tremor in PD and may be an important part of rehabilitation in affected individuals.

Compliance with ethical standards

All participnts of this trial signed the letter of consent, and the ethics of this study was approved by the local ethics committee of the Iran University of Medical Science (reference no. 1395.28471). This trial was registered at (Trial ID: 29803).

Conflict of Interest

The authors declare that they have no conflict of interest.


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Copyright information

© Fondazione Società Italiana di Neurologia 2019

Authors and Affiliations

  1. 1.Neuromusculoskeletal Research Center, Department of Physical Medicine and RehabilitationIran University of Medical SciencesTehranIran
  2. 2.Department of Sport Biomechanics and Technology, Sport Sciences Research InstituteTehranIran
  3. 3.Department of Biomedical EngineeringAmirkabir University of TechnologyTehranIran
  4. 4.Department of NeurologyIran University of Medical SciencesTehranIran
  5. 5.School of Rehabilitation ScienceIran University of Medical SciencesTehranIran

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