Diagnosing acute brain dysfunction due to sepsis

  • Figen Esen
  • Günseli Orhun
  • Perihan Ergin ÖzcanEmail author
  • Andres R. Brenes Bastos
  • Erdem Tüzün
Review Article


Developments in the management of critically ill patients suffering organ dysfunctions have demonstrated that brain is the prominent organ to be effected during critical illness. Acute brain dysfunction due to pathologic neuroinflammatory processes associated with sepsis is commonly seen and related to morbidity and mortality in the ICU treatment. Studies reported that survivors of sepsis may suffer long-term cognitive dysfunction that affects quality of life. However, there are no specific approaches to diagnose acute brain dysfunction in the early phase to target protective measures. In recent years, imaging methods and biomarkers are the most important issues of studies. This review will address the current diagnostic approaches to acute brain dysfunction related to sepsis.


Delirium Neuroimaging Neuroinflammation Septic encephalopathy 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Informed consent

This article is not a clinical trial or experimental study. This article is a review of acute brain dysfunctions.

This article does not contain any studies with human participants and animals performed by any of the authors.


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Copyright information

© Fondazione Società Italiana di Neurologia 2019

Authors and Affiliations

  1. 1.Department of Anesthesiology, Istanbul Faculty of MedicineIstanbul UniversityIstanbulTurkey
  2. 2.Department of Anesthesia, Critical Care and Pain MedicineBeth Israel Deaconess Medical CenterBostonUSA
  3. 3.Department of Neuroscience, Aziz Sancar Institute of Experimental MedicineIstanbul UniversityIstanbulTurkey

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