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The effects of IVIg therapy on serum levels of neuropeptide Y and cytokines in Guillain-Barré syndrome

  • Chunrong Li
  • Tianfei Luo
  • Yanwei Cheng
  • Shan Liu
  • Lifan Qiao
  • Xiujuan Wu
  • Kangding LiuEmail author
Original Article
  • 31 Downloads

Abstract

Background

Guillain-Barré syndrome (GBS) is a common acute immune-mediated inflammatory disorder affecting the peripheral nervous system (PNS) of humans. Studies in humans and in animal models revealed that neuropeptide Y (NPY) levels are altered in some neurodegenerative and neuroimmune disorders. Herein, we investigated the levels of NPY and cytokines in the serum of GBS patients and explored the roles of NPY in the disease severity and its short-term prognosis.

Methods

Twenty patients with GBS (case group) and twenty healthy individuals (control group) were enrolled in this study. NPY levels were analyzed by enzyme-linked immunosorbent assay (ELISA). The levels of pro- and anti-inflammatory cytokines (including interferon-γ (IFN-γ), interleukin (IL)-4, IL-10, IL-12p70, IL-17A, and tumor necrosis factor-α (TNF-α)) were analyzed using cytometric beads array (CBA). The clinical characteristics, disease severity, and short-term prognosis were compared between the two groups.

Results

Compared with the control group, the levels of NPY and cytokines were significantly increased in the serum of patients with GBS. NPY levels in the serum of GBS patients were correlated with the disease severity.

Conclusion

Our results suggest that NPY and cytokines are involved in the pathogenesis of GBS. The levels of NPY can help to predict the severity of the disease.

Keywords

Guillain-Barré syndrome Neuropeptide Y Cytokines Disease severity Short-term prognosis 

Abbreviations

GBS

Guillain-Barré syndrome

PNS

Peripheral nervous system

NPY

Neuropeptide Y

ELISA

Enzyme-linked immunosorbent assay

IFN-γ

Interferon-γ

IL

Interleukin

TNF-α

Tumor necrosis factor-α

CBA

Cytometric beads array

CNS

Central nervous system

MS

Multiple sclerosis

IVIg

Intravenous immunoglobulin

HFGS

Hughes Functional Grading Scale

MRC

Medical Research Council

SPSS

Statistical Product and Service Solutions

EAN

Experimental autoimmune neuritis

PE

Phycoerythrin

Th

Helper T cell

TGF-β

Transforming growth factor β

Notes

Funding information

This study was supported by grants from The First Hospital, Jilin University Changchun, China General Program of the National Natural Science Foundation (No. 81771299).

Compliance with ethical standards

This study was approved by the ethics committee of the First Hospital of Jilin University, Changchun, China.

Conflict of interest

The authors declare that they have no conflicts of interest.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

10072_2019_4063_MOESM1_ESM.xls (30 kb)
ESM 1 (XLS 30 kb)

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Copyright information

© Fondazione Società Italiana di Neurologia 2019

Authors and Affiliations

  1. 1.Neuroscience Center, Department of NeurologyThe First Hospital of Jilin University, Jilin UniversityChangchunChina

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