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Neurological Sciences

, Volume 40, Issue 12, pp 2581–2586 | Cite as

Fear leads to a deficit of prepulse inhibition of blink reflex in healthy humans

  • Ayşegül GündüzEmail author
  • Selen Koçak
  • Sedat Gez
  • Meral E. Kızıltan
Original Article
  • 32 Downloads

Abstract

Objective

We aimed to analyze whether or not fear conditioning exerts an effect on prepulse inhibition (PPI) of blink reflex (BR). To create fear conditioning, we used fearful faces. Since fearful faces lead to a specific set of fear conditioning, we hypothesized PPI of BR would change under the observation of fearful faces.

Method

We included 17 healthy subjects with a mean age of 30.8 ± 6.9 years and seven healthy subjects with a mean age of 57.7 ± 7.3 years between January 2018 and June 2018 and recorded PPI of BR. The recordings were done before observation of any image, during observation of images, and immediately after observation of images. Observation of images included observation of fearful faces for 30 s and a neutral image of a white screen for 30 s (in a randomized order).

Results

There was a R2-PPI deficit during observation of fearful faces in each group whereas R2-PPI fully developed at other time points. R1 amplitude and R2 magnitude were lower during observation of any image compared with baseline and post-observation time points.

Conclusion

In conclusion, a deficit of R2-PPI develops during observation of fearful faces in humans which is probably related to activation of the amygdala.

Keywords

Blink reflex Blink reflex prepulse inhibition Fearful faces 

Notes

Acknowledgments

All authors wish to thank all the volunteers who agreed to participate in the study.

Compliance with ethical standards

All participants provided informed consent.

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Copyright information

© Fondazione Società Italiana di Neurologia 2019

Authors and Affiliations

  • Ayşegül Gündüz
    • 1
    Email author
  • Selen Koçak
    • 1
  • Sedat Gez
    • 1
  • Meral E. Kızıltan
    • 1
  1. 1.Department of Neurology, Cerrahpaşa School of MedicineIstanbul University-CerrahpaşaIstanbulTurkey

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