Neurological Sciences

, Volume 40, Issue 12, pp 2603–2607 | Cite as

Genetic variants within Ninjurin 2 gene are associated with risk of ischemic stroke in Iranian population

  • Vadoud Malekzadeh
  • Iman Azari
  • Rezvan Noroozi
  • Roshanak Shams
  • Mina Farzaneh
  • Mohammad TaheriEmail author
  • Soudeh Ghafouri-FardEmail author
Original Article


Previous genetic and epidemiological studies have shown the contribution of genetic factors in conferring the risk of ischemic stroke. Among the acknowledged risk factors of stroke are the single nucleotide polymorphisms (SNPs) near Ninjurin 2 (NINJ2) gene which encodes a surface adhesion protein. In the current study, we investigated the role of two SNPs near this gene in ischemic stroke in Iranian population. The frequency of the A allele of the rs11833579 was significantly lower in cases compared with controls (OR (95% CI) = 0.68 (0.54–0.86), adjusted P value = 0.002). The rs11833579 was significantly associated with risk of stroke in co-dominant (AA vs. GG: OR (95% CI) = 0.39 (0.23–0.66), adjusted P value = 0.003) and recessive (OR (95% CI) = 0.44 (0.27–0.72), adjusted P value = 0.001) models. The rs3809263 was associated with risk of stroke in dominant model (OR (95% CI) = 1.5 (1.09–2.06), adjusted P value = 0.02). The A C haplotype (rs11833579 and rs3809263) decreased the risk of stroke (OR (95% CI) = 0.72 (0.57–0.91), adjusted P value = 0.03), while the G T haplotype conferred susceptibility to stroke (OR (95% CI) = 1.42 (1.11–1.82), adjusted P value = 0.02). Consequently, the present case-control study supports the role of NINJ2 as a risk locus for ischemic stroke in Iranian population.


Ninjurin 2 NINJ2 Ischemic stroke Cerebrovascular diseases Ninjurin 2 gene variations Polymerase chain reaction 



The current study was supported by a grant from Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Compliance with ethical standards

The study protocol was approved by the ethical committee of Ardabil University of Medical Sciences.

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Fondazione Società Italiana di Neurologia 2019

Authors and Affiliations

  1. 1.Department of Anatomical Sciences, Research Laboratory for Embryology and Stem Cells, School of MedicineArdabil University of Medical SciencesArdabilIran
  2. 2.Department of Medical GeneticsShahid Beheshti University of Medical SciencesTehranIran
  3. 3.Phytochemistry Research CenterShahid Beheshti University of Medical SciencesTehranIran
  4. 4.Urogenital Stem Cell Research CenterShahid Beheshti University of Medical SciencesTehranIran

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