Neurological Sciences

, Volume 40, Issue 12, pp 2573–2579 | Cite as

Dementia trajectory for patients with logopenic variant primary progressive aphasia

  • Michitaka FunayamaEmail author
  • Yoshitaka Nakagawa
  • Asuka Nakajima
  • Taketo Takata
  • Yu Mimura
  • Masaru Mimura
Original Article



The timing of progression of logopenic variant primary progressive aphasia (lvPPA) to severe dementia has not been elucidated. To address this shortcoming, 10 patients with lvPPA were continuously followed.


Patients were assessed with the annual rate of change in the Clinical Dementia Rating (CDR) sum of boxes and period from lvPPA onset to the onset of benchmark signs, including mild, moderate, or severe dementia, episodic memory deficits, topographical disorientation, difficulties with using controls for electronic appliances, and conceptual apraxia. When severe dementia was evident, we also investigated the incidence of severe cognitive and behavioral signs such as neologistic jargon, difficulties in recognizing family members, pica, and mirror sign.


The mean time for patients to reach a particular CDR was as follows: CDR of 1, 4.1 ± 1.3 years post-onset; CDR 2, 5.7 ± 1.6 years; CDR 3, 7.3 ± 1.6 years. The annual rate of change in the CDR sum of boxes was 3.4 ± 1.1, corresponding to 1.7 years for the CDR to increase by 1.0. Difficulties with using electronic controls began at 3.3 ± 1.6 years, episodic memory deficits at 4.0 ± 2.0 years, topographical disorientation at 5.2 ± 2.1 years, and conceptual apraxia at 5.5 ± 2.1 years. For patients who progressed to severe dementia, six could not recognize family members, five exhibited pica, three experienced mirror sign, and one developed neologistic jargon.


Our results suggest that patients with lvPPA progress rapidly to dementia and develop conceptual apraxia, episodic memory deficits, visuospatial deficits, and semantic memory deficits.


S: Logopenic variant primary progressive aphasia Conceptual apraxia Episodic memory deficits Visuospatial deficits Semantic memory deficits 



We thank the patients and their caregivers who participated in this study.

Authors’ contributions

MF, YN, TT, YM, and AN acquired case data. MF designed the study, and drafted the manuscript. MM supervised the study.

Compliance with ethical standards

Competing interests

The authors declare that they have no competing interests.

Patient consent

Informed consent was obtained from each patient and/or their spouse.

Ethics approval

Aspects of the study concerning ethics were approved by the Human Research Ethics Committee of Ashikaga Red Cross Hospital.


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Copyright information

© Fondazione Società Italiana di Neurologia 2019

Authors and Affiliations

  1. 1.Department of NeuropsychiatryAshikaga Red Cross HospitalAshikagaJapan
  2. 2.Department of RehabilitationEdogawa HospitalTokyoJapan
  3. 3.Department of RehabilitationAshikaga Red Cross HospitalAshikagaJapan
  4. 4.Department of NeuropsychiatryKeio University School of MedicineTokyoJapan

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