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Exploring the role of music therapy in multiple sclerosis: brief updates from research to clinical practice

  • Claudia VinciguerraEmail author
  • Nicola De Stefano
  • Antonio Federico
Review Article

Abstract

Background

Physical, cognitive and mood-behavioral disturbances are very common in people with multiple sclerosis (MS) representing a relevant disease burden. Recently, in this field, several studies investigated the role of music therapy (MT) as a complementary therapeutic approach especially in terms of rehabilitation strategy.

Objectives

The aim of this review is to report and discuss the effectiveness of various music-based interventions (MBIs) for clinical outcomes in MS patients.

Data sources

All English medical papers registered in the Web of Knowledge, PubMed, Google Scholar, and ScienceDirect from March 1999 to March 2019.

Inclusion and exclusion criteria

We selected all the articles concerning MBIs in MS including papers that dealt with human samples and excluding non-human samples, reviews and case reports.

Results

Out of 46 articles, we selected 24 papers of which 13 completely following the inclusion criteria were evaluated for the present analysis.

Discussion

We explored the efficacy of several MT programs, taking into account the different aspects of application feasibility in the clinical management of MS patients and the future challenges.

Keywords

Multiple sclerosis (MS) Music-based interventions (MBIs) Music therapy (MT) 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

References

  1. 1.
    Comi G, Radaelli M, Sorensen SP (2017) Evolving concepts in the treatment of relapsing remitting multiple sclerosis. Lancet 389:1347–1356CrossRefGoogle Scholar
  2. 2.
    Sihvonen AJ, Sarkamo T, Leo V et al (2017) Music-based interventions in neurological rehabilitation. Lancet Neurol 16:648–660CrossRefGoogle Scholar
  3. 3.
    Moumdjian L, Sarkamo T, Leone C, Leman M, Feys P (2017) Effectiveness of music- based interventions on motoricity or cognitive functioning in neurological populations: a systematic review. Eur J Phys Rehabil Med 53(3):466–482Google Scholar
  4. 4.
    Raglio A, Attardo L, Gontero G et al (2015) Effects of music therapy on mood in neurological patients. Worl J Psychiatr 5:68–79CrossRefGoogle Scholar
  5. 5.
    Ostermann T, Schmid W (2006) Music therapy in the treatment of multiple sclerosis: a comprehensive literature review. Expert Rev Neurother 6:469–477CrossRefGoogle Scholar
  6. 6.
    Vinciguerra C (2017) Music intervention efficacy in elderly: a promising non-pharmacological approach to cognitive dysfunctions. Neurol Sci 38:933–934CrossRefGoogle Scholar
  7. 7.
    Altenmüller E, Marco-Pallares J, Münte TF, Schneider S (2009) Neural reorganization underlies improvement in stroke-induced motor dysfunction by music-supported therapy. Ann N Y Acad Sci 1169:395–405CrossRefGoogle Scholar
  8. 8.
    Hsu MH, Flowerdew R, Parker M, Fachner J, Odell-Miller H (2015) Individual music therapy for managing neuropsychiatric symptoms for people with dementia and their carers: a cluster randomized controlled feasibility study. BMC Geriatr 15:84CrossRefPubMedCentralGoogle Scholar
  9. 9.
    Chu H, Yang CY, Lin Y et al (2014) The impact of group music therapy on depression and cognition in elderly persons with dementia: a randomized controlled study. Biol Res Nurs 16:209–217CrossRefGoogle Scholar
  10. 10.
    Moumdjian L, Moens B, Vanzeir E et al (2019) A model of different cognitive processes during spontaneous and intentional coupling to music in multiple sclerosis. Ann N Y Acad Sci.  https://doi.org/10.1111/nyas.14023)
  11. 11.
    Seebacher B, Kuisma R, Glynn A, Berger T (2017) The effect of rhythmic-cued motor imagery on walking, fatigue and quality of life in people with multiple sclerosis: a randomised controlled trial. Mult Scler J 23:286–296CrossRefGoogle Scholar
  12. 12.
    Seebacher B, Kuisma R, Glynn A, Berger T (2015) Rhythmic cued motor imagery and walking in people with multiple sclerosis: a randomized controlled feasibility study. Pilot and Feasibility Studies, BMC 1:25.  https://doi.org/10.1186/s40814-015-0021-3
  13. 13.
    Thaut MH, Peterson DA, McIntosh GC et al (2014) Music mnemonics aid verbal memory and induce learning-related brain plasticity in multiple sclerosis. Front Hum Neurosci 8:395.  https://doi.org/10.3389/fnhum.2014.00395 CrossRefPubMedCentralGoogle Scholar
  14. 14.
    Conklyn D, Stough D, Novak E (2010) A home-based walking program using rhythmic auditory stimulation improves gait performance in patients with multiple sclerosis: a pilot study. Neurorehabil Neural Repair 24:835–842CrossRefGoogle Scholar
  15. 15.
    Charlton ME, Gabriel KP, Munsinger T (2010) Program evaluation results of a structured group exercise program in individual with multiple sclerosis. Int J MS Care 12:92–96CrossRefGoogle Scholar
  16. 16.
    Moore KS et al (2008) The effectiveness of music as a mnemonic device on recognition memory for people with multiple sclerosis. J Music Ther 45:307–329CrossRefGoogle Scholar
  17. 17.
    Aldridge D, Schmid W, Kaeder M et al (2005) Functionality or aesthetics? A pilot study of music therapy in the treatment of multiple sclerosis patients. Complementary Therapies in Medicine 13:25–33CrossRefGoogle Scholar
  18. 18.
    Wiens M, Reimer M, Guyn H (1999) Music therapy as a treatment method for improving respiratory muscle strength in patients with advanced multiple sclerosis a pilot study. Rehabil Nurs 24:74–80Google Scholar
  19. 19.
    Baram Y, Miller A (2007) Auditory feedback control for improvement of gait in patients with multiple sclerosis. J Neurol Sci 254:90–94CrossRefGoogle Scholar
  20. 20.
    Grahn JA, Brett M (2007) Rhythm and beat perception in motor areas of the brain. J Cogn Neurosci 19:893–906CrossRefGoogle Scholar
  21. 21.
    Gatti R, Tettamanti A, Lambiase S, Rossi P, Comola M (2015) Improving hand functional use in subjects with multiple sclerosis using a musical keyboard: a randomized controlled trial. Physiother Res Int 20:100–107CrossRefGoogle Scholar
  22. 22.
    Penta M, Tesio L, Arnould C, Zancan A, Thonnard JL (2001) The ABILHAND questionnaire as a measure of manual ability in chronic stroke patients: Rasch-based validation and relationship to upper limb impairment. Stroke 32:1627–1634CrossRefGoogle Scholar
  23. 23.
    Young HJ, Mehta TS, Herman C, Wang F, Rimmer JH (2019) The effects of M2M and adapted yoga on physical and psychosocial outcomes in people with multiple sclerosis. Arch Phys Med Rehabil 100:391–400CrossRefGoogle Scholar
  24. 24.
    Mandelbaum R, Triche EW, Fasoli SE, Lo AC (2015) A pilot study : examining the effects and tolerability of structured dance intervention for individuals with multiple sclerosis. Disabil Rehabil 38:218–222Google Scholar
  25. 25.
    Peterson DA, Thaut MH (2002) Delay modulates spectral correlates in the human EEG of non-verbal auditory working memory. Neurosci Lett 328:17–20CrossRefGoogle Scholar
  26. 26.
    DA Thaut P, McIntosh GC (2005) Temporal entrainment of cognitive functions. Musical mnemonics induce brain plasticity and oscillatory synchrony in neural networks underlying memory. Ann N Y Acad Sci 1060:243–254CrossRefGoogle Scholar
  27. 27.
    Schimdt W, Aldridge D (2004) Active music therapy in the treatment of multiple sclerosis patients: a matched control study. J Music Ther 41:225–240CrossRefGoogle Scholar
  28. 28.
    O’Callaghan C (1999) Lyrical themes in songs written by palliative care patients. Music therapy in palliative care: new voices. Aldridge D. Jessica Kingsley Publishers, London, 43–58Google Scholar
  29. 29.
    Gilberston R, Maryanna KD (2017) Mindfulness in motion for people with multiple sclerosis: a feasibility study. Int J MS Care 19:225–231CrossRefGoogle Scholar
  30. 30.
    Sarkamo T, Ripolles P, Vepsalainem H et al (2014) Structural changes induced by daily music listening in the recovering brain after middle by daily music listening in the recovering brain after middle cerebral artery stroke: a voxel based morphometry study. Front Hum Neurosci 8:245.  https://doi.org/10.3389/fnhum.2014.00245 PubMedCentralGoogle Scholar
  31. 31.
    Molinari M, Leggio MG, De Martin M et al (2003) The neurobiology of rhythmic motor entrainment. Ann N Y Acad Sci 999:313–321CrossRefGoogle Scholar
  32. 32.
    Scholz DS, Rohde S, Nikmaram N, Brückner HP, Großbach M, Rollnik JD, Altenmüller EO (2016) Sonification of arm movements in stroke rehabilitation-a novel approach in neurologic music therapy. Front Neurol 7:106.  https://doi.org/10.3389/fneur.2016.00106 CrossRefPubMedCentralGoogle Scholar
  33. 33.
    Meyer M, Elmer S, Baumann S et al (2007) Short-term plasticity in the auditory system: differential neural responses to perception and imagery of speech and music. Restor Neurol Neurosci 25:411–431Google Scholar
  34. 34.
    Bangert M, Peschel T, Schlaug G, Rotte M, Drescher D, Hinrichs H, Heinze HJ, Altenmüller E (2006) Shared networks for auditory and motor processing in professional pianists: evidence from fMRI conjunction. Neuroimage. 30:917–926CrossRefGoogle Scholar
  35. 35.
    DeDrew MJ, van der Wilk AS, Poppe E et al (2012) Rehabilitation, exercise therapy and music in patients with Parkinson’s disease: a meta-analysis of the effects of music-based movement therapy on walking ability, balance, and quality of life. Parkinsonism Relat Disord 18:114–119Google Scholar
  36. 36.
    Sarkamo T, Tervaniemi M, Latinem S et al (2008) Music listening enhances cognitive recovery and mood after middle cerebral artery stroke. Brain 13:866–876CrossRefGoogle Scholar
  37. 37.
    Thau M, Leins AK, Rice RR et al (2007) Rhythmic auditory stimulation improves gait more than NDT/Bobath training in near-ambulatory patients early poststroke: a single blind randomized trial. Neurorehabil Neural Repair 21:455–459CrossRefGoogle Scholar
  38. 38.
    Rojo N, Amenqual J, Juncadella et al (2011) Music-supported arm training induces plasticity in the sensorimotor cortex in chronic stroke. Brain Inj 25:787–793CrossRefGoogle Scholar
  39. 39.
    Luft AR, McCombe-Waller S, Whitall J, Forrester LW, Macko R, Sorkin JD, Schulz JB, Goldberg AP, Hanley DF (2004) Repetitive bilateral arm training and motor cortex activation in chronic stroke. JAMA. 292:1853–1861CrossRefPubMedCentralGoogle Scholar
  40. 40.
    Amengual JL, Rojo N, Veciana de Las Heras M et al (2013) Sensorimotor plasticity after music-supported therapy in chronic stroke patients revealed by transcranial magnetic stimulation. PLoS One 8(4):e61883.  https://doi.org/10.1371/journal.pone.0061883 CrossRefPubMedCentralGoogle Scholar
  41. 41.
    Pallison J, Roussel-Baclet C, Maillet D et al (2015) Music enhances verbal episodic memory in Alzheimer’s disease. J Clin Exp Neuropsychol 37:503–517CrossRefGoogle Scholar
  42. 42.
    Chiaravalloti ND, DeLuca J (2008) Cognitive impairment in multiple sclerosis. Lancet Neurol 7:1139–1151Google Scholar
  43. 43.
    Tscahcher W, Schildt M, Sander K (2010) Brain connectivity in listening to affective stimuli: a functional magnetic resonance imaging (fMRI) study and implications for psychotherapy. Psychother Res 20:576–588CrossRefGoogle Scholar
  44. 44.
    Salimpoor VN, Benovoy M, Larcher K et al (2011) Anatomically distinct dopamine release during anticipation and experience of peak emotion to music. Nat Neurosci 4:257–262CrossRefGoogle Scholar
  45. 45.
    Okada K, Kurita A, Takase B et al Effects of music therapy on autonomic nervous system activity, incidence of heart failure events, and plasma cytokine and catecholamine levels in elderly patient with cerebrovascular diseases and dementia. Int Heart J 50:95–110Google Scholar
  46. 46.
    McCaffrey T, Edwards J (2016) Music therapy helped me get back doing: perspectives of music therapy participants in mental health services. J Music Ther 53(2):121–148CrossRefGoogle Scholar

Copyright information

© Fondazione Società Italiana di Neurologia 2019

Authors and Affiliations

  1. 1.Department of Medicine, Surgery and NeurosciencesUniversity of SienaSienaItaly

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