Neurological Sciences

, Volume 40, Issue 12, pp 2657–2658 | Cite as

Sporadic adult-onset spinocerebellar ataxias

Reply: Degenerative and acquired sporadic adult-onset ataxia
  • Hélio A. Ghizoni TeiveEmail author
  • Carlos Henrique F. Camargo
  • Renato P. Munhoz
Letter to the Editor

Dear editor:

Lieto et al. [1] wrote a very interesting review article entitled “Degenerative and acquired sporadic adult onset ataxia.” The authors summarized, in practical diagnostic approach, the main sporadic adult-onset ataxias including degenerative non-hereditary, hereditary, and acquired ataxias. [1] This is a very thorough review on the subject; however, we believe that there are some points that deserve further discussion.

In the group of non-hereditary degenerative ataxias, important issues could be discussed. First, in the multiple system atrophy type C, besides the classical cerebellar dysfunction, associated with dysautonomia and also pyramidal signs and parkinsonian and dystonic features, the presence of REM-sleep behavior disorder (RBD) is a very common predictive sign. [2] The RBD is strongly associated with neurodegenerative diseases, particularly synucleinopathies such as multiple system atrophy (MSA). [2] Thus, the quantification of REM sleep can be an important...


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The authors alone are responsible for the content and writing of this paper.

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Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Fondazione Società Italiana di Neurologia 2019

Authors and Affiliations

  1. 1.Movement Disorders Unit, Neurology Service, Internal Medicine Department, Hospital de ClínicasFederal University of ParanáCuritibaBrazil
  2. 2.Graduate Program of Internal Medicine (Neurology), Hospital de ClínicasFederal University of ParanáCuritibaBrazil
  3. 3.Movement Disorders Centre, Toronto Western HospitalUniversity of TorontoTorontoCanada

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