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Neurological Sciences

, Volume 40, Issue 10, pp 2105–2109 | Cite as

Longitudinal study of a cohort of MSA-C patients in South Italy: survival and clinical features

  • Maria Lieto
  • Alessandro Roca
  • Dario Bruzzese
  • Antonella Antenora
  • Girolamo Alfieri
  • Francesco Saccà
  • Marta Bellofatto
  • Leonilda Bilo
  • Stefano Barbato
  • Giuseppe De Michele
  • Alessandro FillaEmail author
Original Article
  • 37 Downloads

Abstract

Sixty-six patients with possible or probable MSA (multiple system atrophy) cerebellar type, personally observed between 2006 and 2018 were retrospectively reviewed. The time point of data collection was January 1, 2019. Forty-nine patients lost independent walking after a median time of 5 years (95% C. I. 4–6). Thirty-two patients were confined to wheelchair after a median time of 7 years (95% C. I. 7–8). Twenty-seven patients were deceased after a median time of 9 years (95% C. I. 8–10). A later onset predicted an earlier loss of independent walking (HR 1.07; 95% C.I. 1.03–1.11; p = 0.001). Higher UMSARS score predicted shorter time to loss of independent walking (HR 1.04; 95% C.I. 1.02–1.06; p = 0.001) and to wheelchair (HR 1.03; 95% C.I. 1.01–1.06; p = 0.021). No predictor of time to death was found.

Keywords

Multiple system atrophy Survival Predictors 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

The study protocol was approved by local Ethics Committee of the Federico II University in Naples.

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Copyright information

© Fondazione Società Italiana di Neurologia 2019

Authors and Affiliations

  • Maria Lieto
    • 1
  • Alessandro Roca
    • 1
  • Dario Bruzzese
    • 2
  • Antonella Antenora
    • 1
  • Girolamo Alfieri
    • 1
  • Francesco Saccà
    • 1
  • Marta Bellofatto
    • 1
  • Leonilda Bilo
    • 1
  • Stefano Barbato
    • 1
  • Giuseppe De Michele
    • 1
  • Alessandro Filla
    • 1
    Email author
  1. 1.Department of Neuroscience, Reproductive and Odontostomatological SciencesFederico II UniversityNaplesItaly
  2. 2.Department of Public HealthFederico II UniversityNaplesItaly

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