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Response of migraine without aura to kudzu

  • Vincenzo Tullo
  • Marcella CuroneEmail author
  • Bruno Colombo
  • Gianni Allais
  • Silvia Sinigaglia
  • Chiara Benedetto
  • Davide Zarcone
  • Maria Gabriella Saracco
  • Marco Aguggia
  • Gennaro Bussone
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Migraine without aura (MO) is the most frequent form of primary headaches; it has a high prevalence (60–80% of all migraines) and frequently is highly disabling, with a significant impact on the social and working life of patients. Lifetime prevalence is between 2 and 10% in men and between 15 and 25% in women. Typical migraine symptoms are uni- or bilateral attacks of throbbing pain lasting from 4 to 72 h, often accompanied by photophobia, phonophobia, nausea, and vomiting. Preventive treatment for migraine helps to reduce disability by decreasing the frequency, severity, and duration of migraine attacks, improving patient’s quality of life (Fig. 1). In the last decade, there has been a growing interest in the use of nutritional supplements (nutraceuticals) in MO prophylaxis, as an alternative to pharmacological treatments. In addition, some investigations highlighted that people who suffer from headaches often prefer treatment with nutraceuticals over traditional pharmacological...

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.

References

  1. 1.
    Ulbricht C, Costa D, Dam C, D’Auria D, Giese N, Isaac R, LeBlanc Y, Rusie E, Weissner W, Windsor RC (2015) An evidence-based systematic review of kudzu (Pueraria lobata) by the natural standard research collaboration. J Diet Suppl 12(1):36–104CrossRefGoogle Scholar
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    Sewell RA (2008) Response of cluster headache to kudzu. Headache 49(1):98–105CrossRefGoogle Scholar
  3. 3.
    Pucci E, Solinas F, Mostardini C et al (2017) Efficacy of KUZIK® in the prophylaxis of migraine without aura: a retrospective observational study. J Headache Pain 18(1):111Google Scholar

Copyright information

© Fondazione Società Italiana di Neurologia 2019

Authors and Affiliations

  • Vincenzo Tullo
    • 1
  • Marcella Curone
    • 1
    Email author
  • Bruno Colombo
    • 2
  • Gianni Allais
    • 3
  • Silvia Sinigaglia
    • 3
  • Chiara Benedetto
    • 3
  • Davide Zarcone
    • 4
  • Maria Gabriella Saracco
    • 5
  • Marco Aguggia
    • 5
  • Gennaro Bussone
    • 1
  1. 1.Neurology DepartmetCasa di Cura del Policlinico - Igea Headache CenterMilanItaly
  2. 2.Neurology DepartmentSan Raffaele HospitalMilanItaly
  3. 3.Women’s Headache Center, Department of Surgical SciencesUniversity of TurinTurinItaly
  4. 4.Neurology Unit Gallarate HospitalASST Valle OlonaGallarateItaly
  5. 5.Neurology DepartmentAsti HospitalAstiItaly

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