Advertisement

A multimodal imaging features of the brain in adult-onset neuronal intranuclear inclusion disease

  • Yajing Liu
  • Jiancong Lu
  • Kai Li
  • Hai Zhao
  • Yanyun Feng
  • Zaiqiang Zhang
  • Lang Hu
  • Guode Li
  • Yan ShaoEmail author
  • Yukai WangEmail author
Letter to the Editor
  • 10 Downloads

Dear Editor,

Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder, with highly variable clinical manifestations such as cerebellar ataxia, neuropathy, and cognitive dysfunction [1], which was characterized pathologically by eosinophilic hyaline intranuclear inclusions in the central and autonomic neurons [2]. However, skin biopsy reveals intranuclear inclusions in somatic cells had been discovered in recent years [3]. Additionally, high signal intensity in the corticomedullary junction on diffusion-weighted imaging (DWI) had been found in NIID patients with leukoencephalopathy diagnosed by a skin biopsy [1]. However, the metabolic alterations of the brain in NIID patients have never been reported. We herein report the case of an adult-onset NIID patient with cognitive dysfunction along with multimodal imaging features of the brain, including MRIs findings and the metabolic alterations of the brain.

A 67-year-old woman was referred to our hospital with...

Notes

Acknowledgements

The authors thank the patient and her family for the cooperation in this study, and thank Weian Chen for his great help in study. This study was supported by the Science and Technology Foundation of Foshan (2016AB001821) and the National Science Foundation of Zhejiang (LY15H090019).

Authors’ contribution

Yajing Liu and Jiancong Lu equally contributed to the paper. Yukai Wang and Yan Shao equally contributed to the paper.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Sone J, Kitagawa N, Sugawara E, Iguchi M, Nakamura R, Koike H, Iwasaki Y, Yoshida M, Takahashi T, Chiba S, Katsuno M, Tanaka F, Sobue G (2014) Neuronal intranuclear inclusion disease cases with leukoencephalopathy diagnosed via skin biopsy. J Neurol Neurosurg Psychiatry 85(3):354–356CrossRefGoogle Scholar
  2. 2.
    Takahashi-Fujigasaki J (2003) Neuronal intranuclear hyaline inclusion disease. Neuropathology 23(4):351–359CrossRefGoogle Scholar
  3. 3.
    Sone J, Tanaka F, Koike H, Inukai A, Katsuno M, Yoshida M, Watanabe H, Sobue G (2011) Skin biopsy is useful for the antemortem diagnosis of neuronal intranuclear inclusion disease. Neurology 76(16):1372–1376CrossRefGoogle Scholar
  4. 4.
    Lin A, Ross BD, Harris K, Wong W (2005) Efficacy of proton magnetic resonance spectroscopy in neurological diagnosis and neurotherapeutic decision making. NeuroRx 2(2):197–214CrossRefGoogle Scholar
  5. 5.
    DeVito TJ, Drost DJ, Neufeld RW, Rajakumar N, Pavlosky W, Williamson P et al (2007) Evidence for cortical dysfunction in autism: a proton magnetic resonance spectroscopic imaging study. Biol Psychiatry 61(4):465–473CrossRefGoogle Scholar
  6. 6.
    Agnieszka S, Łukasz B, Marek K (2017) Metabolic heterogeneity of the normal human brain: multivariate analysis of 1H MRS in vivo spectra acquired at 3T. Metabolomics 13:34CrossRefGoogle Scholar
  7. 7.
    Schaller BJ (2008) Strategies for molecular imaging dementia and neurodegenerative diseases. Neuropsychiatr Dis Treat 4(3):585–612CrossRefGoogle Scholar
  8. 8.
    Berti V, Pupi A, Mosconi L (2011) PET/CT in diagnosis of dementia. Ann N Y Acad Sci 1228:81–92CrossRefGoogle Scholar

Copyright information

© Fondazione Società Italiana di Neurologia 2019

Authors and Affiliations

  • Yajing Liu
    • 1
  • Jiancong Lu
    • 1
  • Kai Li
    • 2
  • Hai Zhao
    • 1
  • Yanyun Feng
    • 1
  • Zaiqiang Zhang
    • 2
  • Lang Hu
    • 1
  • Guode Li
    • 1
  • Yan Shao
    • 1
    Email author
  • Yukai Wang
    • 1
    Email author
  1. 1.Department of NeurologyFoshan Hospital Affiliated to Sun Yat-sen UniversityFoshanChina
  2. 2.Department of Neurology, Beijing Hospital, National Center of GerontologyBeijingChina

Personalised recommendations