Malignant syndrome triggered by influenza A virus infection in a patient with Parkinson’s disease with improvement after intravenous peramivir treatment
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Malignant syndrome, also called parkinsonism-hyperpyrexia syndrome, is a rare medical emergency in patients with Parkinson’s disease (PD). The precipitating events that trigger malignant syndrome in patients with PD are anti-parkinsonian drug withdrawal and stress-related factors [1, 2]. Infection is a major cause of malignant syndrome, and fever is considered the trigger . However, the relationship among malignant syndrome, influenza virus infection, and treatment for influenza virus remains unclear. We herein report a case involving a man with PD who developed malignant syndrome secondary to influenza A virus infection but improved after intravenous peramivir treatment without dantrolene.
A 71-year-old man had an 8-year history of Hoehn–Yahr stage ΙΙΙ PD and lived at home with his wife. His gait was slightly unstable, but he was able to walk independently without a cane. His Movement Disorder Society (MDS)-sponsored revision of the Unified...
We appreciate the cooperation of the patient. We also thank Angela Morben, DVM, ELS, from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript.
K.M., M.B., G. I, and H.I. were the attending doctors in the present case. K.M. drafted the manuscript. S.F. conceived the study, participated in its coordination, and helped to draft the manuscript. All authors read and approved the final manuscript.
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Conflict of interest
The authors declare that they have no competing interests.
Informed consent was obtained from the patient described in this article.