Neurological Sciences

, Volume 40, Issue 2, pp 393–398 | Cite as

Clinical significance of sensory hypersensitivities in migraine patients: does allodynia have a priority on it?

  • Jong-Geun Seo
  • Sung-Pa ParkEmail author
Original Article



This study investigated to identify the clinical significance of allodynia compared with other sensory hypersensitivities (SH) in migraine patients.


New patients with migraine were recruited from a headache clinic, and we collected data regarding their clinical characteristics and identified SH including photophobia, phonophobia, osmophobia, and allodynia. The patients completed the 12-item Allodynia Symptom Checklist, Migraine Disability Assessment Scale (MIDAS), Headache Impact Test-6 (HIT-6), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), Insomnia Severity Index (ISI), Fatigue Severity Scale (FSS), and Migraine-Specific Quality of Life Questionnaire Version 2.1. We divided the patients into three groups: SH with allodynia (group 1), SH without allodynia (group 2), and no SH (group 3). Clinical characteristics, psychosomatic features, and quality of life (QOL) were compared among these groups.


A total of 312 migraine patients participated in the study. Among them, 58 (18.6%), 202 (64.7%), and 52 (16.7%) were allocated to groups 1, 2, and 3, respectively. Chronic migraine, family history of migraine, medication overuse headache, earlier age at onset, longer disease duration, higher headache intensity, and aggravation with physical activity were more prevalent in group 1 than in groups 2 or 3. Scores of the MIDAS, HIT-6, PHQ-9, GAD-7, ISI, and FSS were the highest in group 1, followed by groups 2 and group 3. The lowest QOL was noted in group 1, followed by groups 2 and group 3.


This study revealed that SH in migraine, particularly combined with allodynia, may result in poor clinical outcomes.


Sensory hypersensitivity Migraine Allodynia Quality of life Poor outcome 



The authors thank Ju-Hui Lee, a neuropsychologist, for her help with the completion of self-report questionnaires.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


  1. 1.
    Lipton RB, Stewart WF, Diamond S, Diamond ML, Reed M (2001) Prevalence and burden of migraine in the United States: data from the American migraine study II. Headache 41(7):646–657PubMedCrossRefGoogle Scholar
  2. 2.
    Minen MT, Begasse De Dhaem O, Kroon Van Diest A, Powers S, Schwedt TJ, Lipton R, Silbersweig D (2016) Migraine and its psychiatric comorbidities. J Neurol Neurosurg Psychiatry 87(7):741–749PubMedCrossRefGoogle Scholar
  3. 3.
    Seo JG, Park SP (2018) Significance of fatigue in patients with migraine. J Clin Neurosci 50:69–73PubMedCrossRefGoogle Scholar
  4. 4.
    Kim SY, Park SP (2014) The role of headache chronicity among predictors contributing to quality of life in patients with migraine: a hospital-based study. J Headache Pain 15(1):68PubMedPubMedCentralCrossRefGoogle Scholar
  5. 5.
    Park JW, Chu MK, Kim JM, Park SG, Cho SJ (2016) Analysis of trigger factors in episodic migraineurs using a smartphone headache diary applications. PLoS One 11(2):e0149577PubMedPubMedCentralCrossRefGoogle Scholar
  6. 6.
    Kao CH, Wang SJ, Tsai CF, Chen SP, Wang YF, Fuh JL (2014) Psychiatric comorbidities in allodynic migraineurs. Cephalalgia 34(3):211–218PubMedCrossRefGoogle Scholar
  7. 7.
    Demarquay G, Mauguière F (2016) Central nervous system underpinnings of sensory hypersensitivity in migraine: insights from neuroimaging and electrophysiological studies. Headache 56(9):1418–1438PubMedCrossRefGoogle Scholar
  8. 8.
    Lipton RB, Bigal ME, Ashina S, Burstein R, Silberstein S, Reed ML, Serrano D, Stewart WF, American Migraine Prevalence Prevention Advisory Group (2008) Cutaneous allodynia in the migraine population. Ann Neurol 63(2):148–158PubMedPubMedCentralCrossRefGoogle Scholar
  9. 9.
    Louter MA, Bosker JE, van Oosterhout WP, van Zwet EW, Zitman FG, Ferrari MD, Terwindt GM (2013) Cutaneous allodynia as a predictor of migraine chronification. Brain 136(Pt 11):3489–3496PubMedCrossRefGoogle Scholar
  10. 10.
    Kim SY, Park SP (2016) Cutaneous allodynia and its risk factors in Korean patients with migraine: a survey of two tertiary care hospitals. J Oral Facial Pain Headache 30(4):323–329PubMedCrossRefGoogle Scholar
  11. 11.
    Baykan B, Ekizoglu E, Karli N, Kocasoy-Orhan E, Zarifoglu M, Saip S, Siva A, Ertas M (2016) Characterization of migraineurs having allodynia: results of a large population-based study. Clin J Pain 32(7):631–635PubMedCrossRefGoogle Scholar
  12. 12.
    Lovati C, D'Amico D, Bertora P, Raimondi E, Rosa S, Zardoni M, Bussone G, Mariani C (2010) Correlation between presence of allodynia and sleep quality in migraineurs. Neurol Sci 31(Suppl 1):S155–S158PubMedCrossRefGoogle Scholar
  13. 13.
    Headache Classification Committee of the International Headache Society (IHS) (2013) The international classification of headache disorders, 3rd edition (beta version). Cephalalgia 33(9):629–808CrossRefGoogle Scholar
  14. 14.
    Chu MK, Im HJ, Ju YS, Yu KH, Ma HI, Kim YJ, Kim J, Lee BC (2009) Validity and reliability assessment of Korean Headache Impact Test-6 (HIT-6). J Korean Neurol Assoc 27(1):1–6Google Scholar
  15. 15.
    Seo JG, Park SP (2015) Validation of the Patient Health Questionnaire-9 (PHQ-9) and PHQ-2 in patients with migraine. J Headache Pain 16:65PubMedPubMedCentralCrossRefGoogle Scholar
  16. 16.
    Seo JG, Park SP (2015) Validation of the Generalized Anxiety Disorder-7 (GAD-7) and GAD-2 in patients with migraine. J Headache Pain 16:97PubMedPubMedCentralCrossRefGoogle Scholar
  17. 17.
    Lee J, Shin C, Ko YH, Lim J, Joe SH, Kim S, Jung IK, Han C (2012) The reliability and validity studies of the Korean version of the Perceived Stress Scale. Korean J Psychosom Med 20(2):127–134Google Scholar
  18. 18.
    Cho YW, Lee JH, Son HK, Lee SH, Shin C, Johns MW (2011) The reliability and validity of the Korean version of the Epworth sleepiness scale. Sleep Breath 15(3):377–384PubMedCrossRefGoogle Scholar
  19. 19.
    Cho YW, Song ML, Morin CM (2014) Validation of a Korean version of the insomnia severity index. J Clin Neurol 10(3):210–215PubMedPubMedCentralCrossRefGoogle Scholar
  20. 20.
    Chung KI, Song CH (2001) Clinical usefulness of fatigue severity scale for patients with fatigue, and anxiety or depression. Korean J Psychosom Med 9(2):164–173Google Scholar
  21. 21.
    Seo JG, Park SP (2017) Validation of the Korean Migraine-Specific Quality of Life Questionnaire version 2.1 in episodic and chronic migraine. J Oral Facial Pain Headache 31(3):251–256PubMedCrossRefGoogle Scholar
  22. 22.
    Bayliss M, Batenhorst A (2002) The HIT-6™ a user’s guide. Quality Metric Incorporated, LincolnGoogle Scholar
  23. 23.
    Pfizer. Patient Health Questionnaire (PHQ) screeners. Accessed Sep 2013
  24. 24.
    Pfizer. Patient Health Questionnaire (PHQ) screeners. Accessed Nov 2012
  25. 25.
    Burstein R, Yarnitsky D, Goor-Aryeh I, Ransil BJ, Bajwa ZH (2000) An association between migraine and cutaneous allodynia. Ann Neurol 47(5):614–624PubMedCrossRefGoogle Scholar
  26. 26.
    Mathew NT, Kailasam J, Seifert T (2004) Clinical recognition of allodynia in migraine. Neurology 63(5):848–852PubMedCrossRefGoogle Scholar
  27. 27.
    Benatto MT, Florencio LL, Carvalho GF, Dach F, Bigal ME, Chaves TC, Bevilaqua-Grossi D (2017) Cutaneous allodynia is more frequent in chronic migraine, and its presence and severity seems to be more associated with the duration of the disease. Arq Neuropsiquiatr 75(3):153–159PubMedCrossRefGoogle Scholar
  28. 28.
    Lipton RB, Munjal S, Buse DC, Bennett A, Fanning KM, Burstein R, Reed ML (2017) Allodynia is associated with initial and sustained response to acute migraine treatment: results from the American Migraine Prevalence and Prevention Study. Headache 57(7):026–1040Google Scholar
  29. 29.
    Antonaci F, Nappi G, Galli F, Manzoni GC, Calabresi P, Costa A (2011) Migraine and psychiatric comorbidity: a review of clinical findings. J Headache Pain 12(2):1–11CrossRefGoogle Scholar
  30. 30.
    Mendonça MD, Caetano A, Viana-Baptista M, CHLO Headache Study Group (2016) Association of depressive symptoms with allodynia in patients with migraine: aA cross-sectional study. Cephalalgia 36(11):1077–1081PubMedCrossRefGoogle Scholar
  31. 31.
    Tietjen GE, Brandes JL, Peterlin BL, Eloff A, Dafer RM, Stein MR, Drexler E, Martin VT, Hutchinson S, Aurora SK, Recober A, Herial NA, Utley C, White L, Khuder SA (2009) Allodynia in migraine: association with comorbid pain conditions. Headache 49(9):1333–1344PubMedCrossRefGoogle Scholar

Copyright information

© Fondazione Società Italiana di Neurologia 2018

Authors and Affiliations

  1. 1.Department of Neurology, School of MedicineKyungpook National UniversityDaeguRepublic of Korea

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