Multiple sclerosis and oncocytic thyroid carcinoma: fortuitous or drug-related association?
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To the Editor,
Autoimmune thyroid dysfunction, treatment-related or not, is reported in patients with multiple sclerosis (MS) . We would like to point out another type of thyroid pathology, tumoral, in MS patients, however very rarely encountered. We had recently studied a case of thyroid carcinoma, peculiar by the predominant oncocyte-type component associated to MS.
The patient (man, 28 years) presented with hair loss, diarrhea, thermophobia, tremor, and tachycardia. The medical history revealed allergy (pollen, prawn), and bilateral moderate loss of vision (at the age of 12 years when in North Africa) with probable intermediar uveitis and optic neuritis. Precise data on initial work-up (brain magnetic resonance imaging (MRI), cerebrospinal fluid analysis (CSF), autoimmunity tests, visual evoked potentials) were not available. These complaints may have been a first event of MS. The local team retained a diagnosis of Behcet disease and the patient was treated by oral steroids...
The authors thank Dr. E Maillart as well as Dr. E Sabattini, Dr. B Bisig, Dr. R Scott, Dr. J Smith, Dr. S Singh, Dr. V Vasiliu, and Pr P Gaulard, as well as J Raleche, M Rodrigues, S El Sayeh, V Guzal, C Van Vetteren, I Pluchart, L Jovanov, F Spindler, B Mechekour, N Delva, F Bouchard, F Aurejac, B Mechekour, M De Souza, MC Portenier, and the BIUM and NCA/Avicenne/APHP teams.
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The statements noted on the Internet page of the journal (Instructions for Authors) are fullfilled. Enclosed is the pdf of the Internet page.
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