Neurological Sciences

, Volume 40, Issue 2, pp 433–435 | Cite as

Bilateral middle cerebellar peduncles involvement a malnourished man with Marchiafava-Bignami disease

  • Yaoyao ShenEmail author
  • Zhijuan Cheng
  • Tingmin Dai
  • Hongbing Nie
Letter to the Editor

Dear Editor,

Marchiafava-Bignami disease (MBD), as a rare condition mainly associated with alcoholism and malnutrition, is characterized by demyelination and necrosis of the corpus callosum (CC) [1]. The clinical presentation of MBD can vary from altered mental status, cognitive impairment, gait disturbance, seizure, depression, and even death [2]. The characteristic neuroimaging findings are symmetric lesions of the CC. Extracallosal lesions such as cortex or subcortical white matter have also been well documented in the literature. Nevertheless, MBD involving bilateral middle cerebellar peduncles (MCPs) is relatively rare. Here, we describe a case of MBD with widespread lesions including bilateral MCPs.

An 85-year-old man with a long-term history of chronic obstructive pulmonary disease (COPD) was admitted to our department due to altered mental status, difficulty in walking and speaking for 7 days. Three weeks prior to admission, he was sent to local hospital for expectoration,...


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.


  1. 1.
    Ironside R, Bosanquet FD, McMenemey WH (1961) Central demyelination of the corpus callosum (Marchiafava-Bignami disease) with report of a second case in Great Britain. Brain 84:212–230CrossRefGoogle Scholar
  2. 2.
    Hillbom M, Saloheimo P, Fujioka S, Wszolek ZK, Juvela S, Leone MA (2014) Diagnosis and management of Marchiafava-Bignami disease: a review of CT/MRI confirmed cases. J Neurol Neurosurg Psychiatry 85(2):168–173CrossRefGoogle Scholar
  3. 3.
    Fernandes LMP, Bezerra FR, Monteiro MC, Silva ML, de Oliveira FR, Lima RR et al (2017) Thiamine deficiency, oxidative metabolic pathways and ethanol-induced neurotoxicity: how poor nutrition contributes to the alcoholic syndrome, as Marchiafava-Bignami disease. Eur J Clin Nutr 71(5):580–586CrossRefGoogle Scholar
  4. 4.
    Heinrich A, Runge U, Khaw AV (2004) Clinicoradiologic subtypes of Marchiafava-Bignami disease. J Neurol 251(9):1050–1059CrossRefGoogle Scholar
  5. 5.
    Tuntiyatorn L, Laothamatas J (2008) Acute Marchiafava-Bignami disease with callosal, cortical, and white matter involvement. Emerg Radiol 15(2):137–140CrossRefGoogle Scholar
  6. 6.
    Nalini A, Kovoor JM, Dawn R, Kallur KG (2009) Marchiafava-Bignami disease: two cases with magnetic resonance imaging and positron emission tomography scan findings (2009). Neurol India 57(5):644–648CrossRefGoogle Scholar
  7. 7.
    Xuehan L, Zhiyu LV, Wang P, Chen X (2017) A rare case of Marchiafava-Bignami disease: extracallosal lesions involving bilateral medipeduncle. Neurol India 65(3):642–643CrossRefGoogle Scholar
  8. 8.
    Bellido S, Navas I, Aranda MA, Ginestal R, Venegas B (2012) Unusual MRI findings in a case of Marchiafava Bignami disease. Neurology 78(19):1537CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of NeurologyThe Affiliated Hospital of Jiujiang UniversityJiujiangPeople’s Republic of China
  2. 2.Department of NeurologyThe Second Affiliated Hospital of Nanchang UniversityNanchangPeople’s Republic of China

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