Bilateral middle cerebellar peduncles involvement a malnourished man with Marchiafava-Bignami disease
- 55 Downloads
Marchiafava-Bignami disease (MBD), as a rare condition mainly associated with alcoholism and malnutrition, is characterized by demyelination and necrosis of the corpus callosum (CC) . The clinical presentation of MBD can vary from altered mental status, cognitive impairment, gait disturbance, seizure, depression, and even death . The characteristic neuroimaging findings are symmetric lesions of the CC. Extracallosal lesions such as cortex or subcortical white matter have also been well documented in the literature. Nevertheless, MBD involving bilateral middle cerebellar peduncles (MCPs) is relatively rare. Here, we describe a case of MBD with widespread lesions including bilateral MCPs.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflicts of interest.
- 3.Fernandes LMP, Bezerra FR, Monteiro MC, Silva ML, de Oliveira FR, Lima RR et al (2017) Thiamine deficiency, oxidative metabolic pathways and ethanol-induced neurotoxicity: how poor nutrition contributes to the alcoholic syndrome, as Marchiafava-Bignami disease. Eur J Clin Nutr 71(5):580–586CrossRefGoogle Scholar