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A case of primary angiitis of the central nervous system presenting with diffuse cerebral microbleeds and recurrent intracranial hemorrhage

  • Xiaojuan Han
  • Zaiying Pang
  • Zhou Wang
  • Shangchen Xu
  • Youting Lin
Letter to the Editor
  • 22 Downloads

Dear Editor,

Primary angiitis of the central nervous system (PACNS) refers to a rare single-organ vasculitis that results in inflammation and destruction of the small and medium vessels restricted to brain, spinal cord, and the meninges [1]. It is one of the foremost diagnostic challenges since it produces vague and unspecific signs and symptoms, presents variable laboratory and imaging manifestations, and requires extensive investigation to rule out various differential diagnoses. Biopsy of the brain remains the gold standard diagnostic test. Here, we present a case of PACNS presenting with cerebral microbleeds (CMBs) and recurrent intracranial hemorrhage (ICH).

A 36-year-old man was admitted to our hospital because of sustained confusion after a generalized tonic-clonic seizure 1 week ago. The seizure occurred during sleep, lasted for 30 min and reoccurred 1 day before admission. Over the previous week, the patient was drowsy and dull. He did not experience headache, nausea, or...

Notes

Acknowledgments

This research was supported by grants from the Shandong provincial key research and development plan (2018GSF121009).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

Informed consent was obtained from the patient.

Supplementary material

10072_2018_3595_MOESM1_ESM.docx (818 kb)
ESM 1 (DOCX 817 kb)

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Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of NeurologyShandong Provincial Hospital affiliated to Shandong UniversityJinan CityPeople’s Republic of China
  2. 2.Department of PathologyShandong Provincial Hospital affiliated to Shandong UniversityJinan CityPeople’s Republic of China
  3. 3.Department of NeurosurgeryShandong Provincial Hospital affiliated to Shandong UniversityJinan CityPeople’s Republic of China

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