Neurological Sciences

, Volume 40, Issue 1, pp 227–228 | Cite as

Can we now say that commonalities between restless leg syndrome and migraine exist?

  • Alberto Raggi
News and Views


The recent manuscript by Xinglong Yang and colleagues provided the first relatively reliable estimate of restless leg syndrome (RLS) prevalence among migraine sufferers, which was estimated at 19% (95% CI 14–24%). The implications of the association between the two conditions are wide, and call for further action aimed to address common disease mechanism-associated conditions such as sleep-related ones and associated burden.


Migraine Restless leg syndrome Prevalence Sleep 


Compliance with ethical standards

Conflict of interest

The author declares that there are no conflict of interest.


  1. 1.
    Yang X, Liu B, Yang B, Li S, Wang F, Li K, Hu F, Ren H, Xu Z (2018) Prevalence of restless legs syndrome in individuals with migraine: a systematic review and meta-analysis of observational studies. Neurol Sci.
  2. 2.
    Hening W, Walters AS, Allen RP, Montplaisir J, Myers A, Ferini-Strambi L (2004) Impact, diagnosis and treatment of restless legs syndrome (RLS) in a primary care population: the REST (RLS epidemiology, symptoms, and treatment) primary care study. Sleep Med 5(3):237–246CrossRefGoogle Scholar
  3. 3.
    Rains JC (2018) Sleep and migraine: assessment and treatment of comorbid sleep disorders. Headache 58(7):1074–1091CrossRefGoogle Scholar
  4. 4.
    Steiner TJ, Stovner LJ, Vos T, Jensen R, Katsarava Z (2018) Migraine is first cause of disability in under 50s: will health politicians now take notice? J Headache Pain 19(1):17CrossRefGoogle Scholar
  5. 5.
    Linde M, Gustavsson A, Stovner LJ, Steiner TJ, Barré J, Katsarava Z, Lainez JM, Lampl C, Lantéri-Minet M, Rastenyte D, Ruiz de la Torre E, Tassorelli C, Andrée C (2012) The cost of headache disorders in Europe: the Eurolight project. Eur J Neurol 19(5):703–711CrossRefGoogle Scholar
  6. 6.
    Salas RE, Kwan AB (2012) The real burden of restless legs syndrome: clinical and economic outcomes. Am J Manag Care 18(9 Suppl):S207–S212PubMedGoogle Scholar

Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Neurology, Public Health and Disability UnitFondazione IRCCS Istituto Neurologico Carlo BestaMilanoItaly

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