Neurological Sciences

, Volume 40, Issue 2, pp 413–414 | Cite as

Sudden unexpected death in Parkinson’s disease: why do neuroscientists still ignore this condition?

  • Mariana B. Nejm
  • Monica L. Andersen
  • Sergio Tufik
  • Josef Finsterer
  • Fulvio A. ScorzaEmail author
Letter to the Editor

Although translational studies dramatically increased our understanding of the pathophysiology of Parkinson’s disease (PD) over the last 200 years since its first description, PD is the second most common age-related neurodegenerative disorder after Alzheimer’s disease and entails a major burden in disability, comorbidities, stigma, costs, and even mortality [1, 2]. With this in mind, the results presented in the interesting article recently published by Xue and colleagues [3], which discussed the 100 most cited articles on PD to point out the most impressive advances, developments, and discoveries in this field during the last century, evoked the following questions and considerations with regard to mortality in PD.

Why were neuroscientists in the last century not interested in the mortality of PD? Which are the mortality rates in PD? Can individuals with PD die prematurely? Are there cases of sudden death in PD?

Firstly, it is extremely important to emphasize that sudden cardiac...


  1. 1.
    Poewe W, Seppi K, Tanner CM, Halliday GM, Brundin P, Volkmann J, Schrag AE, Lang AE (2017) Parkinson disease. Nat Rev Dis Primers 3:17013. CrossRefPubMedGoogle Scholar
  2. 2.
    Scorza FA, do Carmo AC, Fiorini AC, Nejm MB, Scorza CA, Finsterer J, Ferraz HB (2017) Sudden unexpected death in Parkinson’s disease (SUDPAR): a review of publications since the decade of the brain. Clinics 72(11):649–651. CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Xue JH, Hu ZP, Lai P, Cai DQ, Wen ES (2018) The 100 most-cited articles in Parkinson’s disease. Neurol Sci (in press) 39:1537–1545. CrossRefGoogle Scholar
  4. 4.
    Abhilash SP, Namboodiri N (2014) Sudden cardiac death: historical perspectives. Indian Heart J 66(Suppl 1):S4–S9CrossRefGoogle Scholar
  5. 5.
    Deo R, Albert CM (2012) Epidemiology and genetics of sudden cardiac death. Circulation 2012 125(4):620–637. CrossRefGoogle Scholar
  6. 6.
    Pinter B, Diem-Zangerl A, Wenning GK, Scherfler C, Oberaigner W, Seppi K, Poewe W (2015) Mortality in Parkinson's disease: a 38-year follow-up study. Mov Disord 30(2):266–269. CrossRefPubMedGoogle Scholar
  7. 7.
    Scorza FA, Fiorini AC, Scorza CA, Finsterer J (2018) Cardiac abnormalities in Parkinson’s disease and Parkinsonism. J Clin Neurosci 53:1–5. CrossRefPubMedGoogle Scholar
  8. 8.
    Matsumoto H, Sengoku R, Saito Y, Kakuta Y, Murayama S, Imafuku I (2014) Sudden death in Parkinson’s disease: a retrospective autopsy study. J Neurol Sci 343(1–2):149–152CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Disciplina de NeurociênciaUniversidade Federal de São Paulo/Escola Paulista de Medicina (UNIFESP/EPM)São PauloBrazil
  2. 2.Departamento de PsicobiologiaUniversidade Federal de São Paulo/Escola Paulista de Medicina (UNIFESP/EPM)São PauloBrazil
  3. 3.Krankenanstalt RudolfstiftungViennaAustria

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