Serum NT-pro CNP levels in epileptic seizure, psychogenic non-epileptic seizure, and healthy subjects
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Epileptic seizure is the result of uncontrollable neural excitation in the brain. The C-type natriuretic peptide is a member of natriuretic peptide hormone family and is synthesized by brain and blood vessels in CNS. NT-pro CNP is an amino-terminal fragment of C-type natriuretic peptide and is more stable compared to its predecessor. In this study, we aimed to evaluate the role of NT-pro CNP in psychogenic non-epileptic seizures, epileptic seizures, and normal subjects.
Thirty-three patients with epilepsy and 43 patients with psychogenic non-epileptic seizures were enrolled in this study. The control group consisted of 28 healthy subjects. Post-ictal serum levels of NT-pro CNP were acquired from all participants. Statistically significant differences between patient groups and controls regarding serum levels of NT-pro CNP were sought.
NT-pro CNP levels were significantly lower in the epilepsy group than the psychogenic non-epileptic seizure group and control group with no significant difference between the psychogenic non-epileptic seizure and control group (p < 0.05).
Post-ictal serum NT-pro CNP levels were lower in epileptic seizures compared to psychogenic non-epileptic seizures as well as healthy controls. We think that such a difference is associated with C-type natriuretic peptide-related neural mechanisms such as altered microcirculation, increased brain-blood barrier permeability, and synaptic stabilization.
KeywordsEpilepsy Psychogenic non-epileptic seizure NT-pro CNP Biomarker
- 9.Stingo AJ, Clavell AL, Heublein DM et al (1992) Presence of C-type natriuretic peptide in cultured human endothelial cells and plasma. Am J Phys 263:1318–1321Google Scholar
- 16.Chang CC, Lui CC, Lee CC et al (2012) Clinical significance of serological biomarkers and neuropsychological performances in patients with temporal lobe epilepsy. BMC Neurol 14:12–15Google Scholar
- 17.Anand-Srivastava MB (2005 Jun) Natriuretic peptide receptor-C signaling and regulation. Peptides 26(6):1044–1059 ReviewGoogle Scholar
- 18.Hu P, Zhao XQ, Wang J, Kong HB, Hu B, Lu L, Qin YH (2014) Paradoxical expressions of natriuretic peptide receptor-C and neutral endopeptidase account for C-type natriuretic peptide decline during the progression of experimental obstructive nephropathy. J Renin-Angiotensin-Aldosterone Syst 15:458–465CrossRefGoogle Scholar
- 22.Boscolo Galazzo I, Storti SF, Del Felice A et al (2015) Patient-specific detection of cerebral blood flow alterations as assessed by arterial spin labeling in drug-resistant epileptic patients. PLoS One 6:10Google Scholar