Neurological Sciences

, Volume 39, Issue 9, pp 1597–1602 | Cite as

Amyloid deposition and CBF patterns predict conversion of mild cognitive impairment to dementia

  • Takayuki Kikukawa
  • Takato AbeEmail author
  • Suzuka Ataka
  • Haruna Saito
  • Itsuki Hasegawa
  • Toshikazu Mino
  • Jun Takeuchi
  • Joji Kawabe
  • Yasuhiro Wada
  • Yasuyoshi Watanabe
  • Yoshiaki Itoh
Original Article


Mild cognitive impairment (MCI) can include the transition from a normal state to dementia. To explore biomarkers for the development of dementia, we performed an 18-month follow-up study in 28 patients with amnestic MCI. Amyloid deposition was examined using PiB PET, and cerebral blood flow (CBF) was examined using SPECT. Cognitive function was periodically assessed. The rate of conversion to dementia was higher in the PiB-positive/equivocal group (74%) than in the PiB-negative group (33%) (p = 0.041). Perfusion SPECT was performed in 16 patients. MCI patients with an AD-characteristic pattern of reduced CBF had a higher PiB-positive/equivocal rate (82%) than those with a non-AD pattern (20%) (p = 0.018), and patients with an AD pattern had a higher conversion rate (82%) than those with a non-AD pattern (40%) (p = 0.094). Clinically, all PiB-positive converters were diagnosed as having Alzheimer’s disease (AD), whereas PiB-negative converters were thought to have some form of dementia other than AD. Amyloid PET is useful for predicting conversion to AD in MCI patients. A pattern analysis of perfusion SPECT findings might also be helpful for predicting conversion to AD, but with a lower specificity.


Alzheimer’s disease Mild cognitive impairment Pittsburg compound B Positron emission tomography Perfusion SPECT 


Authors’ contributions

All the authors have approved the manuscript and agree with its submission.

Compliance with ethical standards

The present clinical study design was approved by the research ethics committee of the Osaka City University Graduate School of Medicine (IRB# 689). Written consent was obtained from all the study participants or from their next of kin.

Conflict of interest

The authors declare that they have no conflicts of interest.


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Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2018

Authors and Affiliations

  • Takayuki Kikukawa
    • 1
  • Takato Abe
    • 1
    Email author
  • Suzuka Ataka
    • 1
  • Haruna Saito
    • 1
  • Itsuki Hasegawa
    • 1
  • Toshikazu Mino
    • 1
  • Jun Takeuchi
    • 1
  • Joji Kawabe
    • 2
  • Yasuhiro Wada
    • 3
  • Yasuyoshi Watanabe
    • 3
  • Yoshiaki Itoh
    • 1
  1. 1.Department of NeurologyOsaka City University Graduate School of MedicineOsakaJapan
  2. 2.Department of Nuclear MedicineOsaka City University Graduate School of MedicineOsakaJapan
  3. 3.Molecular Probe Dynamics LaboratoryRIKEN Center for Life Science TechnologiesKobeJapan

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