Polymorphisms in the interleukin-1β (IL-1B) and interleukin-1α (IL-1A) genes on risk of febrile seizures: a meta-analysis
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The aim of the current study was to clarify the role of four common genetic polymorphisms in the interleukin-1β (IL-1B) and interleukin-1α (IL-1A) genes on risk of febrile seizures (FS) by means of meta-analyses. We searched for studies published until February 2018 using ISI Web of Science, Pubmed, Wanfang, and Chinese National Knowledge Infrastructure databases. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using MetaAnalyst version Beta 3.13. Seventeen case-control studies were included for meta-analysis. For the IL-1B rs16944 polymorphism, the summary analysis of studies conducted among Caucasian populations showed a significant association in the CT+TT versus CC contrast (OR 1.434, 95% CI 1.153–1.785), while the pooled analysis for Asian populations yielded a significant estimate in the TT versus CC+CT comparison (OR 1.393, 95% CI 1.051–1.846). No association was observed between the IL-1B rs1143627, IL-1B rs1143634, and IL-1A rs1800587 polymorphisms and FS risk. Sensitivity analyses excluding studies showing deviation from Hardy-Weinberg equilibrium did not alter conclusions. The findings of our meta-analysis suggest that the IL-1B rs16944 polymorphism may be an important genetic determinant for FS in Caucasian and Asian populations.
KeywordsFebrile seizures Interleukin-1 Meta-analysis
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Conflict of interest
The authors declare that there is no conflict of interest.
- 4.Aggelakis K, Zacharaki F, Dardiotis E, Xiromerisiou G, Tsimourtou V, Ralli S, Gkaraveli M, Bourpoulas D, Rodopoulou P, Papadimitriou A, Hadjigeorgiou G (2010) Interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms in Greek multiple sclerosis (MS) patients with bout-onset MS. Neurol Sci 31:253–257CrossRefPubMedGoogle Scholar
- 9.Li S, Hu C, Liu T (2006) Relationship between the children interleukin 1β (−511) gene polymorphisms and susceptibility to febrile seizures. Chin J Pathophysiol 22:1168–1170Google Scholar
- 11.Li S, Hu C, Ma W (2007) Analysis of interleukin-1 receptor antagonist gene polymorphisms of children with febrile seizures. J Appl Clin Pediatr 22:521–522Google Scholar
- 16.Wang H, Chen Q, Xiong L (2013) Relationship of interleukin-1β and interleukin-1 receptor antagonist gene polymorphisms with febrile seizures. Chin J Gener Pract 11:1209–1297Google Scholar
- 17.Ren X, Sun S, Liu F, Wang X (2014) Association of IL-1β-511T gene rs16944 polymorphism with febrile seizures. Chin J Contemp Pediatr 16:181–184Google Scholar
- 18.Jing M, Hua Y, Wang Y (2015) Analysis of IL-lα-889C/T genetic polymorphisms of children with febrile seizure. Women Health Res 23:4–5Google Scholar
- 21.Al Morshedy S, Elsaadany HF, Ibrahim HE, Sherif AM, Farghaly MA, Allah MA, Abouzeid H, Elashkar SS, Hamed ME, Fathy MM, Khalil AM, Noah MA, Hegab MS, Ahmed AR, Hashem MI, Emam AA, Anany HG, Ibrahim BR, Gawish HH, Nabil RM, Fattah LA, Alsayed SF (2017) Interleukin-1β and interleukin-1receptor antagonist polymorphisms in Egyptian children with febrile seizures: a case-control study. Medicine (Baltimore) 96:e6370CrossRefGoogle Scholar
- 25.Vezzani A, Conti M, De Luigi A, Ravizza T, Moneta D, Marchesi F, De Simoni MG (1999) Interleukin-1beta immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: functional evidence for enhancement of electrographic seizures. J Neurosci 19:5054–5065CrossRefPubMedGoogle Scholar