Neurological Sciences

, Volume 39, Issue 9, pp 1625–1627 | Cite as

Neurobehçet, multiple sclerosis or overlap syndrome? A case report

  • Vittorio ManteroEmail author
  • Andrea Rigamonti
  • Anna Fiumani
  • Luisa De Toni Franceschini
  • Ugo Pozzetti
  • Roberto Balgera
  • Andrea Salmaggi
Letter to the Editor

Dear Editor,

According to the “McDonald criteria”, multiple sclerosis (MS) diagnosis requires the demonstration of dissemination in time (DIT) and in space (DIS) and no better explanation [1].

We report the case of a 25-year-old woman came to our attention complaining of sudden decrease of vision in both eyes and orbital pain increased by eye movements. Few years before, she had been diagnosed with Behçet’s disease (BD) on the basis of recurrent bilateral uveitis, oral aphthosis, positive pathergy test and positive HLAB51 and treated with methotrexate, infliximab, and prednisone, all suspended for personal decision from 5 years. At the age of 18, after 3 years of therapy with infliximab and 8 years after the diagnosis of BD, she reported a right sensory hemisyndrome and a brain MRI (without gadolinium for allergy) showed T2-weighted hyperintense lesions in the corpus callosum, bilateral centrum semiovale, and corona radiata.

On admission, visual acuity was 1/20 in the right and motus...


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.


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Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Neurological DepartmentA. Manzoni HospitalLeccoItaly
  2. 2.Department of Internal MedicineA. Manzoni HospitalLeccoItaly

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